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differential antibodies antibody arthritis classification cryofibrinogenemia cytoplasmic inflammatory joint management monoarthritis monoarticular msk myopathies myopathy myositis nuclear oligoarthritis oligoarticular pain
Antinuclear Antibody Testing - Nuclear and Cytoplasmic Patterns Nuclear Patterns: • Homogeneous pattern: -
Antinuclear Antibody ... phenomenon, SjS, cancer ... - SLE, SjS, RA ... #differential #diagnosis ... #rheumatology
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Positive ANA ≠ Autoimmune ... context of other symptoms ... , Interstitial Pulmonary ... #patterns #rheumatology ... #diagnosis #differential
Inflammatory Myopathies Dermatomyositis • Onset: Subacute • Pattern: Proximal • CK: Up to 50X ULN • Autoantibodies:
Associated Features: Cancer-associated ... heliotrope, shawl sign ... exclusion Necrotizing Autoimmune ... : Proximal and distal ... #comparison #rheumatology
Approach to Joint Pain - Arthritis Differential Diagnosis Framework Inflammatory Versus Noninflammatory Pain • Is it inflammatory
noninflammatory Signs ... constitutional symptoms ... weeks) Can Be Caused ... Symmetrical: • RA ... #MSK #rheumatology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
overlaps with RA ... ab • RF • Antinuclear ... , INC risk PE, Pulmonary ... Nephrogenic DI Hematologic ... Sjogrens #Syndrome #Rheumatology
Cryofibrinogenemia Summary Cryofibrinogenemia Epidemiology: • 40-70 years with a modest female predominance Cryofibrinogenemia: • The precipitation of a
Cryofibrinogenemia Symptoms ... associated with autoimmune ... Biopsy: Typical pathologic ... #rheumatology # ... hematology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
often causes arthritis ... Presentation - Systemic Symptoms ... purpura: strong sign ... ) pattern: antibodies ... #rheumatology #
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
• Anti-TIF1 (cancer-associated ... Gottron sign) ... pattern of muscle ... statins - probably caused ... Myositis #Myopathy #rheumatology
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