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Vasculitis Involving the Skin - Differential Diagnosis Framework

Primary: 50% Cutaneous Vasculitis: Leukocytoclastic Vasculitis
Secondary: CTD: SLE, RA
the Skin - Differential ... Associated: - Microscopic ... polyangiitis ... - EGPA - GPA ... #skin #dermatology
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
- Purpura - Skin ... Syndrome: • Clinical ... reticularis & skin ... - GPA, EGPA, microscopic ... polyangiitis
ANCA-Associated Vasculitis
There are many definitions, but most come down to the presence of granulomas (pathologically or
ANCA-Associated Vasculitis ... pathologically or clinically ... inflammation: • Microscopic ... (GPA) • Both asthma ... #differential #
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA)

Skin involvement in granulomatosis with polyangiitis (GPA) is common and
(GPA) Skin involvement ... Rarely dominate the clinical ... reticularis Differential ... Polyarteritis nodosa • Microscopic ... #GPA #dermatology
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
PR3-ANCA): • Microscopic ... Polyangiitis: ... , EGPA, microscopic ... Serologies for Cryoglobulins ... #rheumatology #
Diagnosis of IgA Vasculitis (Henoch-Schönlein Purpura) - French Vasculitis Study Group 

1) Suggestive clinical manifestations
1) Suggestive clinical ... individuals - Clinical ... from 45 to 85% : microscopic ... HSP #Diagnosis #Rheumatology ... #Peds #Pediatrics
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
Vasculitis - Differential ... Elevated ESR and CRP GCA ... develop in pts with GCA ... (PR3-ANCA)): Microscopic ... Diagnosis #Rheumatology
Causes of Petechial Rash - Differential Diagnosis Algorithm

Pinpoint areas (less than 2 mm) of hemorrhage, which
Petechial Rash - Differential ... RA, Sjogren's, GPA ... , EGPA, Microscopic ... immunoglobulins & cryoglobulins ... • Skin biopsy
Giant cell arteritis (GCA)

Giant cell arteritis (GCA) definition: Most common systemic inflammatory vasculitis in older adults
systemic inflammatory vasculitis ... Diagnosis = clinical ... very remarkable w/differential ... in literature (NEJM ... required due to skip