11 results
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Diagnosis Framework ... Kasabach-Merritt syndrome ... /HSP • Cryoglobulinemia ... #hematology #rheumatology ... #nonpalpable #dermatology
Vasculitis Involving the Skin - Differential Diagnosis Framework

Primary: 50% Cutaneous Vasculitis: Leukocytoclastic Vasculitis
Secondary: CTD: SLE, RA
Petechiae, Palpable purpura ... : • Behcet Disease ... • Cogan syndrome ... #skin #dermatology ... #rheumatology #
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA)

Skin involvement in granulomatosis with polyangiitis (GPA) is common and
GPA causes disease ... • Mixed cryoglobulinemia ... • Goodpasture syndrome ... #dermatology #rash ... #diagnosis #rheumatology
Dermatological semiology of Cutaneous Vasculitis 

Clinicopathologic correlations
 • Purpura, papules, pustules, necrosis: involvement of small vessels
correlations • Purpura ... Connective tissue disease ... (5%): PAN > GPA ... #dermpath #dermatology ... signs #lesions #diagnosis
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• Autoimmune diseases ... Labs/Diagnosis: ... - GPA, EGPA, microscopic ... #types #classification ... #rheumatology #
Classification of Vasculitis 
Vasculitis of large vessels 
 - Arteritis temporalis (giant-cell arteritis) 
 - Takayasu
Classification of ... granulomatosis - microscopic ... - purpura-arthralgia-nephritis ... #Diagnosis #Rheumatology ... #Diagnosis
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
PR3-ANCA): • Microscopic ... > PR3 60% • GPA ... , EGPA, microscopic ... #rheumatology # ... classification
Skin Conditions Associated with Joint Pain

Rash
	• Human parvovirus B19 infection

Malar rash
	• SLE
	• Human parvovirus B19 infection
	•
Sarcoidosis • GPA ... Antiphospholipid-antibody syndrome ... Sarcoidosis #dermatology ... #differential #diagnosis ... #rheumatology
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
Diagnosis Framework ... Differential Diagnosis ... (PR3-ANCA)): Microscopic ... / ANCA + MPO) Cryoglobulinemic ... #Rheumatology
Cryofibrinogenemia Summary

Cryofibrinogenemia Epidemiology:
 • 40-70 years with a modest female predominance

Cryofibrinogenemia:
 • The precipitation of a
malignancies, vasculitis ... Skin necrosis • Purpura ... Antiphospholipid syndrome ... #rheumatology # ... hematology