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diagnosis antibodies classification dermatology ana antinuclear autoantibodies cryoglobulinemia cryoglobulins cutaneous dermatologic erythematosus gpa granulomatosis lupus myopathy myositis patterns polyangiitis skin
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
Associations ANA ... common in SLE, autoimmune ... c-ANCA - Vasculitis ... Microscopic polyangiitis ... #table #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
- Differential ... ): • Microscopic ... mucositis - Rash ... Dx: GPA, EGPA, microscopic ... #rheumatology #
Vasculitis Involving the Skin - Differential Diagnosis Framework Primary: 50% Cutaneous Vasculitis: Leukocytoclastic Vasculitis Secondary: CTD: SLE, RA
the Skin - Differential ... • ANCA Associated ... : - Microscopic ... : • Behcet Disease ... #rheumatology #
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Using fluorescence microscopy ... Positive ANA ≠ Autoimmune ... Thyroid, Autoimmune ... #patterns #rheumatology ... #diagnosis #differential
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA) Skin involvement in granulomatosis with polyangiitis (GPA) is common and
Maculopapular rash ... reticularis Differential ... Polyarteritis nodosa • Microscopic ... #rash #diagnosis ... #rheumatology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Vasculitis - Differential ... Differential Diagnosis ... , mucositis • Rash ... )): Microscopic ... #Rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
permanent alopecia Differential ... Diagnosis: • ANCA-associated ... • Non-autoimmune ... rheumatologic diseases ... Erythematosus #Diagnosis #Rheumatology
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
infection • Autoimmune ... diseases: - 10% ... DDX: • ANCA (Antineutrophil ... - GPA, EGPA, microscopic ... classification #rheumatology
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
- Differential ... Symptoms: • Gottron rash ... (also seen in association ... Myositis #Myopathy #rheumatology ... #differential #
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