6 results
Autoantibodies and their Disease Associations
ANA - Non-specific; common in SLE, autoimmune hepatitis
Anti-CCP, Rheumatoid factor - RA
Anti-dsDNA
their Disease Associations ... c-ANCA - Vasculitis ... granulomatosis p-ANCA ... Microscopic polyangiitis ... #table #rheumatology
Classification of Vasculitis 
Vasculitis of large vessels 
 - Arteritis temporalis (giant-cell arteritis) 
 - Takayasu
small vessels - ANCA-associated ... granulomatosis - microscopic ... - systemic lupus ... dermatomyositis #Size ... #Diagnosis #Rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
- ANCA specific ... ): • Microscopic ... Vasculitis: + MPO-ANCA ... Dx: GPA, EGPA, microscopic ... differential #diagnosis #rheumatology
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
findings (ANA, ... Diagnosis: • ANCA-associated ... vasculitis, rheumatoid ... antibodies • (-) ANA ... Erythematosus #Diagnosis #Rheumatology
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases

• Septic arthritis - Gram stain and culture of
Rheumatology Workup ... polarized light microscopy ... antibody (ANA) ... ACE level, CXR, ANCA ... #Disease #Rheumatoid
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• Autoimmune diseases ... DDX: • ANCA (Antineutrophil ... - GPA, EGPA, microscopic ... (e.g. systemic lupus ... #rheumatology #