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diagnosis algorithm injury management transaminitis aclf acute bypass calling chemistry cirrhosis complications consultation drug failure function gastric giconsult hepatitis idiosyncratic
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
presentation • Chronic ... - ongoing ↑ LFTs ... disease 6-9 mo ... Idiosyncratic #differential ... #hepatology
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Tests (LFTs) - ... Cirrhosis • Chronic ... (>1000): • DILI ... #LFTs #Differential ... #Diagnosis #hepatology
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
months without treatment ... disease, liver ... Injury (DILI) ... #Cirrhosis #Hepatology ... #gastroenterology
The Liver Consult Primer - Guide to calling a consult HPI: - Start with reason for consult
- Vitals - LFTs ... current MELD - Chronic ... liver disease work ... Calling #Referral #Hepatology ... #Gastroenterology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
- Differential ... • Iatrogenic: DILI ... extrahepatic source - Tests ... • NASH, Chronic ... diagnosis #algorithm #hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs ... disease: > 2 ... • NASH, Chronic ... chemistry #diagnosis #differential ... #Hepatology #transaminitis
Complications after Bariatric Surgery Post Bariatric Intestinal Failure: • Severe protein malnutrition after bariatric surgery • More
nutrients • TPN for treatment ... Liver Disease in ... excluded limb • Treatment ... and Hepatology ... #diagnosis #differential
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