11 results
Inherited Qualitative Platelet Defects
Bernard-Soulier Syndrome
 • Defect of adhesion due to a lack of GP Ib/IX/V
receptor] • Thrombocytopenia ... MYH9-Related Disorder ... chain IIA • Thrombocytopenia ... #table #differential ... #diagnosis #hematology
Platelet disorders and Aggregometry
Glanzmann Thrombasthenia
 • Defective aggregation to all agonists except ristocetin
 • Normal platelet,
Platelet disorders ... with qualitative defects ... #disorders #hematology ... #hemepath #differential ... #diagnosis #Aggregometry
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... Diagnosis Framework ... • Platelet defects ... - Hemolytic anemia ... #Diagnosis #hematology
Blood Disorders - Markers and Differential Diagnosis Algorithm 
Acute
 • Myloid (AML) - CD13, CD33, CD34,
Blood Disorders ... Diagnosis Algorithm ... T-cell - CD7, CD3 Chronic ... Pelger-Huet, Macrocytic anemia ... #Disorders #hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
and Platelet Disorders ... - Differential ... plateletcount), peripheral blood ... changes), high MCV anemia ... #Platelet #Disorders
Hemolytic Anemia - Differential Diagnosis Algorithm
 • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... - Differential ... with or without platelet ... Schistocytes, thrombocytopenia ... Consider RBC membrane disorder
Hodgkin's Lymphoma Overview

Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
• Autoimmune disorders ... Weight loss • Anemia ... Immune hemolytic anemia ... - Low Hb and platelets ... Immunohistochemical studies (to differentiate
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
are a group of disorders ... (thrombocytopenia ... Marrow Failure • Chronic ... count with differential ... Myelodysplastic #Syndromes #diagnosis
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
Chronic Lymphocytic ... lymphoproliferative disorders ... Lymphocytosis: Absolute blood ... • Neutropenia, anemia ... , thrombocytopenia
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura

Activity of von Willebrand factor-cleaving protease activity - A
for Thrombotic Thrombocytopenic ... low, tests to detect ... of Peripheral blood ... WBC count and differential ... #Workup #Hematology