pathology hemepath differential dermatology table diagnosis disorders platelet thrombocytopenia anemia hodgkins defects workup cell cll mds

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11 results

Inherited Qualitative Platelet Defects
Bernard-Soulier Syndrome
• Defect of adhesion due to a lack of GP Ib/IX/V

Blood Disorders - Markers and Differential Diagnosis Algorithm
Acute
• Myloid (AML) - CD13, CD33, CD34,

CD10 - T-cell ... Pelger-Huet, Macrocytic anemia ... • Lymphoid (CLL ... - B-cell ... - Amy Chung, MD

Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
• Lymphocytes accumulate in large numbers

lymphoproliferative disorders ... • Neutropenia, anemia ... , thrombocytopenia ... #workup #oncology ... #hematology

Hemolytic Anemia - Differential Diagnosis Algorithm
• Sickle cells - Consider sickle cell disease (diverse genotypes):

Consider sickle cell ... with or without platelet ... Schistocytes, thrombocytopenia ... Consider RBC membrane disorder ... #workup #hematology

Platelet disorders and Aggregometry
Glanzmann Thrombasthenia
• Defective aggregation to all agonists except ristocetin
• Normal platelet,

Platelet disorders ... with qualitative defects ... #disorders #hematology ... #hemepath #differential ... #diagnosis #Aggregometry

Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
- Prior platelet count, family

and Platelet Disorders ... Diagnosis and Workup ... changes), high MCV anemia ... #Platelet #Disorders ... #Workup #hematology

Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly

are a group of disorders ... formed or don’t work ... count (thrombocytopenia ... blood count with differential ... Myelodysplastic #Syndromes #diagnosis

Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
• Mechanical Trauma (Microangiopathic hemolytic anemia):

) (e.g. lupus, CLL ... lymphoproliferative disorders ... Hemoglobinopathies (e.g. sickle cell ... Extravascular #Causes #differential ... #diagnosis #hematology

Hodgkin's Lymphoma Overview

Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It

• Autoimmune disorders ... Weight loss • Anemia ... Workup: • Full ... - Low Hb and platelets ... Immunohistochemical studies (to differentiate

Solitary Cell Plasmacytoma

What?
• Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma)
• In 3%

Solitary Cell Plasmacytoma ... • Plasma cell neoplasms ... MM, the plasma cell ... #Solitary #Cell ... #Workup #Hematology

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