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differential hematology management signs symptoms workup arthritis bandemia causes cbc cell disease endocin erythematosus gravesdisease hemophagocytic hlh hyperthyroidism laboratory lupus
Graves’ Disease: Pathogenesis and Clinical Findings B & T lymphocyte mediated autoimmunity attack TSH receptor -> Continuous
Pathogenesis and Clinical ... thyroglobulin, Thyroid ... GravesDisease #pathophysiology ... #endocin #endocrinology ... symptoms #signs #diagnosis
Hyperthyroidism Overview Clinical Manifestation of Hyperthyroidism: • Fatigue • Weight loss • Heat intolerance • Depression, nervousness
Hyperthyroidism Overview Clinical ... hyperthyroidism Diagnosis ... ↑ T3 - Mild hypercalcemia ... hyperthyroidism #causes #diagnosis ... #differential #endocrinology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH) Pathophysiology ... →Activation of CD8 ... accumulation of clinical ... Assessment • Clinical ... treatment #summary #rheumatology
Bandemia Overview Normal: < 1% Clinically significant: > 10% Band neutrophils are slightly less mature than segmented neutrophils and
Normal: < 1% Clinically ... Differential Diagnosis ... likelihood of negative clinical ... neutrophil #WBC #CBC ... #hematology #pathophysiology
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
Rheumatology Workup ... exclude myositis • Thyroid ... (to support a diagnosis ... ANA and RF (if clinical ... #testing #Rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
) Suspect: Clinical ... Differential Diagnosis ... Non-autoimmune rheumatologic ... disorders (e.g. thyroid ... #Rheumatology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Sjogren's Syndrome Diagnosis ... /aggregate) of CD4 ... salivary ducts Clinical ... and peripheral Thyroid ... Sjogrens #Syndrome #Rheumatology
Solitary Cell Plasmacytoma What? • Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma) • In 3%
plasmacytoma) Clinical ... Diagnosis? ... CRAB - no anemia, hypercalcemia ... • CBC + diff • ... #Workup #Hematology
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