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diagnosis differential lfts alp chemistry hepatitis phosphatase transaminitis abnormal alkphos astalt biliary bilirubin cholangitis cirrhosis comparison disease enzymes functiontest hellp
Liver Function Test (LFTs) Elevation AST - Cardiac and skeletal muscle, kidney, brain ALT - More specific for
(LFTs) Elevation ... ) vs Indirect (Hemolytic ... Transaminase >> Alkaline ... Cholestatic Pattern - Alkaline ... Transaminitis #diagnosis #hepatology
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm ALP: - Enzymes that catalyze hydrolysis of organic phosphate
(ALP) Elevation ... Differential Diagnosis Algorithm ... disturbance (obstructed liver ... Highest • Bone • Liver ... #hepatology
Low Alkaline Phosphatase - Hypophosphatasia Is Low Alkaline Phosphatase Of Clinical Importance? ALP enzyme- Discovered in 1923 Low
synthesized in: liver ... collection with EDTA Pathophysiology ... eliminated • Elevation ... phosphate &/or • Elevation ... Hyophosphatasia #hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Bilirubin - +/- elevation ... or amyloid: • Elevation ... Enzyme Elevation ... Bilirubin: RBC (hemolysis ... #differential #Hepatology
Liver Disease in Pregnancy Intrahepatic Cholestasis of Pregnancy (ICP) • Onset/Trimester: 25-32 weeks • Typical clinical features:
to 10-20-fold elevation ... HELLP Syndrome (Hemolysis ... to 10-20-fold elevation ... of Pregnancy (AFLP ... Disease #Pregnancy #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Differential Diagnosis Algorithm ... Bilirubin - +/- elevation ... Enzyme Elevation ... differential #diagnosis #algorithm ... #hepatology
Liver Chemistry Tests - AST, ALT, Alkaline Phosphatase and Bilirubin Metabolism AST and ALT: • AST: liver
Tests - AST, ALT, Alkaline ... Alkaline phosphatase ... hepatocyte - Elevation ... AlkPhos #Bilirubin #Hepatology ... #Pathophysiology
Abnormal liver function tests algorithm. This figure details the initial response to abnormal liver blood tests.
tests algorithm ... magnitude of enzyme elevation ... ALP, alkaline phosphatase ... LFTs #Abnormal #Algorithm ... #Hepatology #Liver
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
65 years PBC Pathophysiology ... Examination: • Skin ... PBC Labs: • Alkaline ... obstruction • ALP ... diagnosis #workup #hepatology
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