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diagnosis differential management workup algorithm chemistry injury laboratory thrombocytopenia transaminitis abnormal aflp alkaline alkphos anorexianervosa arthritis biliary bilirubin causes cholangitis
Liver Chemistry Tests - AST, ALT, Alkaline Phosphatase and Bilirubin Metabolism AST and ALT: • AST: liver
and Bilirubin Metabolism ... #ASTALT #AlkPhos ... #Bilirubin #Hepatology ... #Pathophysiology ... #Diagnosis #LFTs
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Liver Chemistries ... Interpretation of LFTs ... AST:ALT Ratios ... #differential #Hepatology ... transaminitis #LFTs
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
Patterns of Liver ... NASH, Genetic / Metabolic ... #Patterns #Liver ... #Injury #hepatology ... #LFTs #transaminitis
Acute Fatty Liver of Pregnancy (AFLP) Pathophysiology: • Defect in fetal free fatty acid metabolism products →
) Pathophysiology ... free fatty acid metabolism ... Intermediate fatty acid metabolism ... Pregnancy #hepatology ... diagnosis #management #pathophysiology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
• Metabolic/Hereditary ... GGT/5-NT: ↑ - ALP ... disease - If ALP ... be abnormal AST ... diagnosis #algorithm #hepatology
Abnormal liver function tests algorithm. This figure details the initial response to abnormal liver blood tests.
clinical symptoms/signs ... The presence of metabolic ... ALP, alkaline phosphatase ... #LFTs #Abnormal ... #Algorithm #Hepatology
Low Alkaline Phosphatase - Hypophosphatasia Is Low Alkaline Phosphatase Of Clinical Importance? ALP enzyme- Discovered in 1923 Low
synthesized in: liver ... collection with EDTA Pathophysiology ... respiratory failure • Neurologic ... Nephrolithiasis • Metabolic ... Hyophosphatasia #hepatology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
(CVID, WAS), (neurologic ... gastric bypass), LFT ... (liver disease) ... not required in all ... Causes #Workup #hematology
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
65 years PBC Pathophysiology ... failure PBC Signs ... obstruction • ALP ... or higher • Liver ... diagnosis #workup #hepatology
Portopulmonary Hypertension Presence of pulmonary arterial hypertension in a patient with portal hypertension No other obvious causes (chronic
m/s • Other signs ... pressure < 15mmHg TREATMENT ... through reduced cGMP metabolism ... hemodynamics Liver ... diagnosis #management #hepatology
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