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diagnosis management syndrome cirrhosis laboratory rheumatology workup abnormal activation algorithm alkaline alkphos alp anorexianervosa arthritis astalt biliary causes chemistry cholangitis
Bilirubin Metabolism - Pathophysiology • Conjugated Bilirubin • Unconjugated Bilirubin By Dr. Khushboo Gala @LouLectures #Bilirubin #Metabolism #Pathophysiology
Bilirubin Metabolism ... - Pathophysiology ... • Conjugated Bilirubin ... #Metabolism #Pathophysiology ... #hepatology #Liver
Liver Chemistry Tests - AST, ALT, Alkaline Phosphatase and Bilirubin Metabolism AST and ALT: • AST: liver
Metabolism AST ... metabolism: • ... Tests #Laboratory #Metabolism ... #Hepatology #Pathophysiology ... #Diagnosis #LFTs
Hepatitis B - Treatment Indications Treatment not indicated: • Immune tolerant state - HBe-Ag detectable, high HBV
-40 years • Low ... undetectable, low ... injury (INR > 2, bilirubin ... mg/dL) or acute liver ... Indications #management #hepatology
Abnormal liver function tests algorithm. This figure details the initial response to abnormal liver blood tests.
Abnormal liver function ... clinical symptoms/signs ... The presence of metabolic ... #LFTs #Abnormal ... #Algorithm #Hepatology
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
65 years PBC Pathophysiology ... failure PBC Signs ... slightly elevated • Bilirubin ... or higher • Liver ... diagnosis #workup #hepatology
Low Alkaline Phosphatase - Hypophosphatasia Is Low Alkaline Phosphatase Of Clinical Importance? ALP enzyme- Discovered in 1923 Low
synthesized in: liver ... collection with EDTA Pathophysiology ... respiratory failure • Neurologic ... Nephrolithiasis • Metabolic ... Hyophosphatasia #hepatology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... WBC >100k, + lab signs ... Lysis Syndrome: • Pathophysiology ... , Elevated Cr, Low ... diagnosis #management #hematology
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Diagnosis: HLH signs ... Splenomegaly • Low ... lymph node, or liver ... • Bicytopenia Treatment ... #hematology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
inflammatory disease How ... thrombocytopenia • Liver ... ↑ AST ↑ ALT ↑ bilirubin ... Treatment: • Corticosteroids ... Diagnosis #Management #Hematology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Prolonged PT/PTT • Low ... protein C and S Pathophysiology ... DIC • Severe Liver ... + Bleeding Treatment ... #management #hematology
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