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diagnosis management differential syndrome algorithm alkaline alp anorexianervosa apml arteritis biliary cholangitis cirrhosis complications differentiation enzymes gca giantcell hyophosphatasia leukostasis
Polycythemia Vera (PV) - Diagnosis and Management Summary Diagnostic Criteria: • Elevated hemoglobin and/or hematocrit AND •
JAK2 mutation OR Abnormally ... When present, symptoms ... , signs, and complications ... • "Vasomotor" symptoms ... #hematology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... Dehydration • Symptoms ... WBC >100k, + lab signs ... Lysis Syndrome: • Pathophysiology ... diagnosis #management #hematology
Abnormal liver function tests algorithm. This figure details the initial response to abnormal liver blood tests.
suspicious clinical symptoms ... /signs should be ... The presence of metabolic ... #LFTs #Abnormal ... #Algorithm #Hepatology
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
65 years PBC Pathophysiology ... failure PBC Signs ... and Symptoms: ... • ALT & AST normal ... diagnosis #workup #hepatology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Triggers: ATRA treatment ... Pathophysiology ... Diagnosis: >3 symptoms ... 500 mg QD until normal ... diagnosis #management #hematology
Low Alkaline Phosphatase - Hypophosphatasia Is Low Alkaline Phosphatase Of Clinical Importance? ALP enzyme- Discovered in 1923 Low
collection with EDTA Pathophysiology ... mineralization Symptoms ... respiratory failure • Neurologic ... Nephrolithiasis • Metabolic ... Hyophosphatasia #hepatology
Giant cell arteritis (GCA) Giant cell arteritis (GCA) definition: Most common systemic inflammatory vasculitis in older adults
with systemic, neurologic ... systemic sx + signs ... 50 in GCA, but normal ... Treatment of GCA ... GCA #Temporal #Signs
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
monophasic Pathophysiology ... • Bilateral signs ... and/or symptoms ... Sjogren's • CSF: - Abnormal ... Transverse Myelitis Treatment
Anorexia Nervosa: Complications CARDIAC ABNORMALITIES - Functional: Low BP, Sinus bradycardia, prolonged QT interval - Structural: Reduced
/ Hypovolemia NEUROLOGIC ... Cerebral Atrophy and Metabolic ... and memory loss HEMATOLOGIC ... #diagnosis #signs ... #symptoms #psychiatry
TAFRO TAFRO syndrome was first described in 2010, standing for: - Thrombocytopenia - Anasarca - Fever - Reticulin fibrosis - Organomegaly TAFRO syndrome
thrombocytopenia syndrome (SFTS ... cell lymphoma Pathophysiology ... and the systemic symptoms ... phosphatase - Normal ... Hypoalbuminemia Treatment
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