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diagnosis management treatment betadglucan differential galactomannan latenttb pulmonary tb tuberculosis abscess aspergillus biomarkers causes comparison ct cxr falsepositives humoral immunity
Miliary Pattern - Chest Radiology • Miliary opacities are scattered, small (1 -4 mm) nodules •
Miliary Pattern - Chest ... throughout the lungs ... Opacities: • Infectious ... - Endemic fungi ... pulmonary #CXR #clinical
Tuberculosis Overview 10 million new M. tuberculosis infections/year Facultative intracellular rod-shaped bacteria Multidrug-resistant tuberculosis (MDR-TB) accounts for 4.6% of
tuberculosis (LTBI) Pathophysiology ... affecting the lungs ... (NTM) • Fungal ... • Progressive lung ... characteristic features Clinical
Fungal Biomarkers: Beta-D-Glucan and Aspergillus Galactomannan Beta-D-Glucan: • Polysaccharide cell wall component of many fungi • Pathogens:
component of many fungi ... infection (IFI) ... cut-offs defined in clinical ... admin of mold-active ... closely related fungi
Tuberculosis Overview 10 million new M. tuberculosis infections/year Facultative intracellular rod-shaped bacteria Multidrug-resistant tuberculosis (MDR-TB) accounts for 4.6% of
tuberculosis (LTBI) Pathophysiology ... affecting the lungs ... (NTM) • Fungal ... • Progressive lung ... characteristic features Clinical
Lung Abscess - Diagnosis and Management Summary Lung Abscess Etiology: • Necrosis of lung parenchyma by a
polymicrobial infection ... Abscess Pathophysiology ... Lung Abscess - Clinical ... level seen • Chest ... Prevotella • Fungal
1,3-Beta-D-Glucan and Galactomannan Testing Sensitivity Specificity and False Positives 1,3-Beta-D-Glucan • Cell wall component of many fungi
component of many fungi ... surfaces, Albumin, Infections ... concurrent admin mold-active ... result in + as long ... closely related fungi
Humoral Immunity - Pathogenesis and Clinical Findings Antigens (Ag) are produced from pathogens (bacteria, viruses, fungi, parasites)
Pathogenesis and Clinical ... bacteria, viruses, fungi ... helper T cells and activate ... Memory B cells are long-lived ... Humoral #Immunity #pathophysiology
Mycoses HISTOPLASMOSIS • Inhalation of conidia → Yeast → travel to lymph nodes → spread in body • Bird
has five major clinical ... aches, joint pain, chest ... stain of clinical ... Aspergillosis Pathophysiology ... ) #Mycoses #InfectiousDiseases
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