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diagnosis differential management causes lfts pbc primary abnormal alkaline biliary phosphatase psc aflp ascites chronic classification comparison disorders elevated elevation
Cholestatic Liver Disease: Primary Biliary Cirrhosis vs Primary Sclerosing Cholangitis #pathophysiology #pbc #psc #hepatology #comparison
Cholestatic Liver ... Primary Biliary Cirrhosis ... Primary Sclerosing Cholangitis ... #pathophysiology ... #pbc #psc #hepatology
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
65 years PBC Pathophysiology ... /Liver failure ... PBC Signs and Symptoms ... obstruction • ALP ... diagnosis #workup #hepatology
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm ALP: - Enzymes that catalyze hydrolysis of organic phosphate
Differential Diagnosis Algorithm ... Highest • Bone • Liver ... Most common symptoms ... Primary biliary Cholangitis ... #hepatology
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis Hepatocellular Pattern (ALT or AST > ALP):
Abnormal Liver Function ... Differential Diagnosis Algorithm ... or AST > ALP): ... Congenital, Others, Cirrhosis ... #diagnosis #hepatology
Hepatomegaly - Differential Diagnosis Algorithm Malignant • Primary Carcinoma • Metastases • Lymphoma • Leukemia • Polycythemia
Differential Diagnosis Algorithm ... Non-Malignant • Fatty Liver ... • Bacterial Cholangitis ... Primary Biliary Cirrhosis ... #Causes #Hepatology
Primary Biliary Cirrhosis - Diagnosis Algorithm Symptoms: Fatigue, Pruritus, Right upper quadrant discomfort Signs: Jaundice, Xanthelasmata, Hepatomegaly Associated history:
- Diagnosis Algorithm ... Symptoms: Fatigue ... Elevated ALP 2. ... Liver biopsy findings ... #hepatology
Causes of Ascites - Differential Diagnosis Algorithm Portal Hypertension - Prehepatic: • Portal vein thrombosis • Splenic
Differential Diagnosis Algorithm ... - Hepatic: • Cirrhosis ... disease • Acute liver ... Primary biliary cholangitis ... #Hepatology #causes
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... Differential Diagnosis Algorithm ... Infiltrative • Cirrhosis ... Others #LFTs #Hepatology ... Differential #Diagnosis #Algorithm
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Differential Diagnosis Algorithm ... disease - If ALP ... hepatitis: < 1 • Cirrhosis ... differential #diagnosis #algorithm ... #hepatology
The 6 C’s of Primary Sclerosing Cholangitis (PSC) PSC is a chronic, cholestatic, immune-mediated disease characterized by
Primary Sclerosing Cholangitis ... • CHOLANGITIS ... • CIRRHOSIS - ... Care focuses on symptom ... management #summary #Hepatology
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