9 results
Metformin Associated Lactic Acidosis (MALA) 

Pathophysiology of MALA
 - Metformin interferes with the activity of the
Associated Lactic Acidosis ... (MALA) Pathophysiology ... acidosis including ... LacticAcidosis #Toxicity ... #Toxicology #Diagnosis
Salicylate Toxicity - Diagnosis and Management

Consider if:
1) Patient is hot and altered
2) You see tachypnea with
Salicylate Toxicity ... show anion-gap metabolic ... acidosis 4) Presentation ... #Toxicology #diagnosis ... #management #Treatment
Intercalated cells response to Metabolic Alkalosis and Metabolic Acidosis
 • Type B Intercalated Cell - "B"
Alkalosis and Metabolic ... Acidosis • Type ... Muner Mohamed @MunerMohamed1 ... Intercalated #cells #pathophysiology ... #nephrology
Citrate Anticoagulation Toxicity

Hypernatremia (HyperNa):
 - Citrate solutions may have ↑ sodium content and should be paired
Anticoagulation Toxicity ... think citrate toxicity ... Acidosis: - Citrate ... Metabolic alkalosis ... #toxicology #nephrology
There are similarities and differences between these 3 conditions which all carry treatment implications. Each mimic
which all carry treatment ... The metabolism of ... algorithm #management #treatment ... #criticalcare # ... foamed
Methotrexate Renal Toxicity 
Prevention:
 • Alkalinize the urine, keep urine ph >7
 • Start pre-treatment 12
Methotrexate Renal Toxicity ... fluids till you see metabolic ... alkalosis • Forced ... Methotrexate #Renal #Toxicity ... #nephrology
The crusade against “Ab”Normal Saline continues.  This is a non-physiologic fluid that can harm our
inevitably leads to Metabolic ... Acidosis. ... Metabolic Acidosis ... #foamed #criticalcare ... management #diagnosis #treatment
Posterior Reversible Encephalopathy Syndrome (PRES) Overview

Clinico-Radiological Syndrome, characterized by:
 • Headache
 • Seizures
 • Altered mental
Etiology: • Pathophysiology ... Medication/Drug toxicity ... , Metabolic disturbance ... epilepticus Treatment ... underlying cause • Treatment
Gitelman Syndrome Overview

What?
• Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter
• Gitelman's syndrome
Hypochloremic metabolic ... Renal tubular acidosis ... Rhabdomyolysis Treatment ... Syndrome #diagnosis #nephrology ... #management #pathophysiology