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17 results

Metformin Associated Lactic Acidosis (MALA)

Pathophysiology of MALA
- Metformin interferes with the activity of the

Associated Lactic Acidosis ... (MALA) Pathophysiology ... use in cellular metabolism ... acidosis including ... LacticAcidosis #Toxicity

Colchicine Toxicity
Naturally-occurring plant alkaloid [Autumn Crocus and Glory Lilly]
2-24 hrs
• Severe GI distress

Colchicine Toxicity ... Renal failure • Metabolic ... acidosis • ARDS ... #Colchicine #Toxicity ... Toxicology #Symptoms #Signs

Salicylate Toxicity - Diagnosis and Management

Consider if:
1) Patient is hot and altered
2) You see tachypnea with

Salicylate Toxicity ... show anion-gap metabolic ... acidosis 4) Presentation ... Acidosis, Respiratory ... diagnosis #management #Treatment

Refeeding Syndrome: Pathogenesis and clinical findings

Patients at Risk of Refeeding Syndrome:
- Little or no nutritional

• Incr Glucose Metabolism ... Syndrome - Metabolic ... Acidosis • Shift ... Syndrome #diagnosis #pathophysiology ... #symptoms #signs

Intercalated cells response to Metabolic Alkalosis and Metabolic Acidosis
• Type B Intercalated Cell - "B"

cells response to Metabolic ... Alkalosis and Metabolic ... Acidosis • Type ... Muner Mohamed @MunerMohamed1 ... Intercalated #cells #pathophysiology

$Hypochloremia - Differential Diagnosis Algorithm Cause - Decreased Intake: • Low salt in diet • Exclusive D5W$

Excessive vomiting - Metabolic ... - Gitelman SIGNS ... increase may cause metabolic ... acidosis - Cl ... Diagnosis #Algorithm #Pathophysiology

DKA DIAGNOSTIC CRITERIA:
1. Serum glucose >250 mg/dL
2. Arterial pH <7.3
3. Serum bicarbonate <18 mEq/L
4. At least

significant anion gap metabolic ... acidosis and ketonemia ... Common, early signs ... Treatment with IV ... gap closes and acidosis

There are similarities and differences between these 3 conditions which all carry treatment implications. Each mimic

which all carry treatment ... Ketosis (SK), acidosis ... The metabolism of ... algorithm #management #treatment ... #criticalcare #foamed

Propofol-Related Infusion Syndrome (PRIS)

Diagnosis is based on a constellation of clinical suspicion and biochemical signs including:

and biochemical signs ... Hyperlactatemia • Metabolic ... acidosis • Rhabdomyolysis ... #Pharmacology #Toxicity

Heat Illnesses and Heat Stroke - Differential Diagnosis Framework

Heat Cramps:
• Muscle pain or spasm -

• Labs: - Metabolic ... acidosis - Rhabdomyolysis ... Collapse: • Pathophysiology ... → Syncope • Signs ... - Mild lactic acidosis

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