13 results
High Anion Gap Metabolic Acidosis (HAGMA) - Differential Diagnosis - GOLDMARK

Glycols - ethylene and propylene glycol
Oxoproline
High Anion Gap Metabolic ... during hypoxic metabolism ... with short bowel syndrome ... Aspirin - salicylate toxicity ... #Anion #Gap #Metabolic
Metformin Associated Lactic Acidosis (MALA) 

Pathophysiology of MALA
 - Metformin interferes with the activity of the
(MALA) Pathophysiology ... use in cellular metabolism ... via anaerobic metabolism ... includes symptoms of metabolic ... LacticAcidosis #Toxicity
Salicylate Toxicity - Diagnosis and Management

Consider if:
1) Patient is hot and altered
2) You see tachypnea with
Salicylate Toxicity ... show anion-gap metabolic ... Labs: Anion-Gap Metabolic ... Alkalosis, High Lactate ... diagnosis #management #Treatment
Refeeding Syndrome: Pathogenesis and clinical findings

Patients at Risk of Refeeding Syndrome:
 - Little or no nutritional
• Incr Glucose Metabolism ... - Metabolic ... Acidosis • Shift ... #diagnosis #pathophysiology ... #symptoms #signs
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis

The most common causes of hyperlactatemia are usually:
impairment of cellular metabolism ... sweat) - its metabolism ... perfusion - shock->treatments ... before beginning treatment ... - Compartment syndrome
Propofol-Related Infusion Syndrome (PRIS)

Diagnosis is based on a constellation of clinical suspicion and biochemical signs including:
Propofol-Related Infusion Syndrome ... and biochemical signs ... Hyperlactatemia • Metabolic ... acidosis • Rhabdomyolysis ... #Pharmacology #Toxicity
DKA DIAGNOSTIC CRITERIA:
1. Serum glucose >250 mg/dL
2. Arterial pH <7.3
3. Serum bicarbonate <18 mEq/L
4. At least
significant anion gap metabolic ... Common, early signs ... production, the rate of metabolism ... Treatment with IV ... diabeticketoacidosis #aniongap
Anion Gap Metabolic Acidosis (AGMA) Differential Diagnosis - MUDPILES and GOLDMARK

M - Methanol
U - Uremia
D -
Anion Gap Metabolic ... Acidosis (AGMA) ... (short bowel syndrome ... and paraldehyde toxicity ... GOLDMARK #Anion #Gap #Metabolic
Weakness - Differential Diagnosis Framework

Approach To Weakness:
 • Non-neuromuscular disorder (Cardiac, pulmonary etc)
 • CNS ->
Radiation • Metabolic ... - Carbamate toxicity ... Lack of UMN/LMN signs ... Hypothyroid • Metabolic ... CPK aldolase, lactate
There are similarities and differences between these 3 conditions which all carry treatment implications. Each mimic
which all carry treatment ... The metabolism of ... convert Pyruvate to Lactate ... for Refeeding Syndrome ... algorithm #management #treatment