8 results
Diabetes Pathophysiology and Medication Targets

The ominous octet is one concept that summarizes the different pathophysiologic pathways
Diabetes Pathophysiology ... pathways that lead ... #Pathophysiology ... Medication #Targets #Drug ... #Endocrinology
Woltman’s sign on Physical Exam

53-year-old man presented with fatigue and sensitivity to cold. A physical examination
relaxation of the ankle ... anorexia nervosa, diabetes ... #PhysicalExam # ... Hypothyroidism #Ankle ... Video #Neurology #Endocrinology
Feedback Loop: Growth Hormone (GH)
Growth Hormone:
 • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
activates JAK-STAT pathway ... activates lipolysis Signs ... thickness) - metabolic ... #FeedbackLoop #endocrinology ... #pathophysiology
Euglycemic Diabetic Ketoacidosis (EuDKA)
SGLT2 Inhibitors
Increasing Indications
Significant Adverse Drug Effects
Definition of EuDKA
 • Metabolic acidosis with pH
Euglycemic Diabetic ... Significant Adverse Drug ... Definition of EuDKA • Metabolic ... level < 200 mg/dL Pathophysiology ... diagnosis #management #endocrinology
Diabetic Ketoacidosis (DKA) - Pathogenesis and Clinical Findings
 • Note: in DKA, body K+ is lost
Diabetic Ketoacidosis ... Due to neuronal metabolism ... Signs/Symptoms/Complications ... DiabeticKetoacidosis #DKA #pathophysiology ... #endocrinology
Pathogenesis of Select Causes of Constipation in Adults and in Elderly

 • Mechanical (ex. Bowel Obstruction,
bowel contents • Metabolic ... Narrowed anorectal angle ... unknown, many pathways ... colonic motility • Drugs ... #constipation #pathophysiology
Abnormalities in Rate and Rhythm of Breathing 
Normal 
The respiratory rate is about 14—20 per min
, anxiety, and metabolic ... be secondary to diabetic ... coma, drug-induced ... Occasional sighs ... Abnormal #Diagnosis #PhysicalExam
Nail Pathologies - Findings in or Near Nails

Paronychia 

A superficial infection of the proximal and lateral
causes include diabetes ... photosensitive drug ... failure, and diabetes ... Diagnosis #Clinical #Signs ... #PhysicalExam #