11 results
Pathogenesis and Pathophysiology of Diabetic Ketoacidosis (DKA)

DKA is a result of an absolute or relative insulin
of Diabetic Ketoacidosis ... of carbohydrate metabolism ... state and fat metabolism ... #DKA #Diabetes ... #Endocrinology
Pathophysiology of Diabetic Ketoacidosis (DKA) and Hyperglycemic Hyperosmolar Syndrome (HHS)
Absolute Insulin deficit:
 - Type I DM:
Pathophysiology ... (DKA) and Hyperglycemic ... Hyperosmolar Syndrome ... Polydipsia #dka ... #comparison #endocrinology
Ketosis Disorders
Ketone bodies are a normal metabolic energy source. Excessive unregulated production of ketones, often accompanied
bodies are a normal metabolic ... fatty acid (FA) metabolism ... of re-feeding syndrome ... • Diabetic ketoacidosis ... diagnosis #management #endocrinology
Diabetic Ketoacidosis (DKA) - Pathogenesis and Clinical Findings
 • Note: in DKA, body K+ is lost
Diabetic Ketoacidosis ... Due to neuronal metabolism ... #pathophysiology ... #endocrinology ... #diabetes
Lactic Acidosis - Differential Diagnosis Framework

Type A: Impaired O2 Delivery (DO2)
 • Decreased O2 Delivery: Hypotension
Ischemia, Compartment Syndrome ... Inborn Errors of Metabolism ... Leukemia/Lymphoma), Diabetes ... Mellitus +/- DKA ... in Short Bowel Syndrome
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis

The most common causes of hyperlactatemia are usually:
impairment of cellular metabolism ... sweat) - its metabolism ... - Compartment syndrome ... • Type B1: - Diabetes ... mellitus/DKA
5-Oxoprolinuria
What is it:
 • Aka pyroglutamic acidosis, Intermediate in γ-glutamyl cycle
 • Amino acid transport and
What is it: • Aka ... Inborn errors of metabolism ... impairment • Type 2 diabetes ... undetectable • Lactic ... organic acid screen Treatment
Refeeding Syndrome Overview

What Is It?
	• Electrolyte/fluid shifts caused by initiation of nutrition in severely malnourished patient.
Refeeding Syndrome ... from hormonal and metabolic ... Poorly controlled diabetes ... hyperparathyroidism Treatment ... Differential #Diagnosis #Pathophysiology
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
Constitutional Syndromes ... cells to repair DNA ... propylthiouracil) - β-lactam ... aplastic anemia Treatment ... Anemia #oncology #hematology
There are similarities and differences between these 3 conditions which all carry treatment implications. Each mimic
But we also have Lactic ... The metabolism of ... for Refeeding Syndrome ... drips unless also diabetic ... DKA is essentially