27 results
Pathogenesis and Pathophysiology of Diabetic Ketoacidosis (DKA)

DKA is a result of an absolute or relative insulin
of Diabetic Ketoacidosis ... of carbohydrate metabolism ... state and fat metabolism ... #DKA #Diabetes ... #Endocrinology
DKA DIAGNOSTIC CRITERIA:
1. Serum glucose >250 mg/dL
2. Arterial pH <7.3
3. Serum bicarbonate <18 mEq/L
4. At least
patients with type 2 diabetes ... have new-onset diabetes ... are Euglycemic Diabetic ... significant anion gap metabolic ... production, the rate of metabolism
Ketosis Disorders
Ketone bodies are a normal metabolic energy source. Excessive unregulated production of ketones, often accompanied
bodies are a normal metabolic ... fatty acid (FA) metabolism ... • Diabetic ketoacidosis ... (DKA) - caused ... diagnosis #management #endocrinology
Diabetic Ketoacidosis (DKA) - Pathogenesis and Clinical Findings
 • Note: in DKA, body K+ is lost
Diabetic Ketoacidosis ... out of cells may cause ... Due to neuronal metabolism ... #pathophysiology ... #endocrinology
Metabolic Alkalosis - Differential Diagnosis Algorithm - Urinary Chloride
 • Cl- responsive metabolic alkalosis
Metabolic Alkalosis ... Cl- responsive metabolic ... Post-hypercapneic metabolic ... acidosis: Diabetic ... #causes #urinary
Skin Ulcers of the Lower Legs / Feet - Differential Diagnosis Algorithm
Physical:
• Pressure
• Trauma
• Radiation
Vascular:
• Arterial
Differential Diagnosis Algorithm ... Neurological: • Diabetic ... dorsalis (syphilis) Metabolic ... gangrenosum • Diabetic ... #causes
Hyperphosphatemia - Differential Diagnosis Algorithm
Transcellular Shift:
 • Rhabdomyolysis
 • Tumor Lysis
 • Metabolic or Respiratory Acidosis
Differential Diagnosis Algorithm ... Tumor Lysis • Metabolic ... Differential #Diagnosis #Algorithm ... #endocrinology ... #causes
Pediatric Vomiting - Gastrointestinal and Systemic Causes - Differential Diagnosis Algorithm
Hepatobiliary:
 • Acute Hepatitis
 • Acute
Differential Diagnosis Algorithm ... malrotation Endocrine/Metabolic ... Pregnancy • Diabetes ... / DKA • Uremia ... #Causes #Peds #
Metabolic Alkalosis - Urinary Chloride Algorithm
Cl- responsive metabolic alkalosis
 • Kidney loss of Cl-
Metabolic Alkalosis ... Urinary Chloride Algorithm ... Cl- responsive metabolic ... acidosis • Diabetic ... the indicated causes
Euglycemic Diabetic Ketoacidosis (EuDKA)
SGLT2 Inhibitors
Increasing Indications
Significant Adverse Drug Effects
Definition of EuDKA
 • Metabolic acidosis with pH
Euglycemic Diabetic ... Definition of EuDKA • Metabolic ... level < 200 mg/dL Pathophysiology ... #Euglycemic #Diabetic ... diagnosis #management #endocrinology