17 results
Vitamin D Metabolism

#VitaminD #Metabolism #Pathophysiology #Endocrinology #Pathways
Vitamin D Metabolism ... #VitaminD #Metabolism ... #Pathophysiology ... #Endocrinology
Vitamin D Metabolism Pathways

Dr. Jamie Willows @jamiekwillows

#VitaminD #Metabolism #Pathways #pathophysiology #endocrinology
Vitamin D Metabolism ... jamiekwillows #VitaminD ... #Metabolism #Pathways ... #pathophysiology ... #endocrinology
Vitamin D Metabolism
Fat-soluble vitamin
Sources: dermal synthesis and food (dairy products, fish)
Active form: calcitriol (1,25-OH Vitamin D)
Main
Vitamin D Metabolism ... Fat-soluble vitamin ... mendesthiagob #VitaminD ... #Metabolism #endocrinology ... #pathophysiology
Hyperparathyroidism - Primary vs Secondary vs Tertiary 
Lab Comparison:
 • Primary Hyperparathyroidism: ↑→PTH, ↑Calcium, ↑Vitamin D,
PTH, ↑Calcium, ↑Vitamin ... PTH, ↓→Calcium, ↓Vitamin ... Symptoms: Commonly no signs ... Hyperparathyroidism #diagnosis #endocrinology ... Secondary #Tertiary #pathophysiology
Woltman’s sign on Physical Exam

53-year-old man presented with fatigue and sensitivity to cold. A physical examination
Woltman’s sign on ... relaxation of the ankle ... Hypothyroidism #Ankle ... Delayed #Clinical #Video ... #Neurology #Endocrinology
Woltman’s sign on Physical Exam - Delayed relaxation phase of the ankle jerk reflex, seen in
Woltman’s sign on ... #Woltmans #sign ... PhysicalExam #clinical #video ... hypothyroidism #endocrinology ... #ankle #reflex
Feedback Loop: Growth Hormone (GH)
Growth Hormone:
 • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
activates lipolysis Signs ... thickness) - metabolic ... #FeedbackLoop #endocrinology ... #pathophysiology
Hypothyroid Myopathy
Very common (up to 80% ) in patients with hypothyroidism
Pathophysiology:
 • T4 deficiency leads to
hypothyroidism Pathophysiology ... mitochondrial oxidative metabolism ... Hypothyroid #Myopathy #pathophysiology ... #signs #symptoms ... #endocrinology
Woltman sign - Delayed Relaxation Phase of deep tendon reflex in severe hypothyroidism

#Woltman #sign #hypothyroidism #clinical
Woltman sign - Delayed ... hypothyroidism #Woltman #sign ... hypothyroidism #clinical #video ... #endocrinology ... #ankle #reflex
Woltman’s sign on Physical Exam

Delayed relaxation phase of a deep-tendon reflex, seen in hypothyroidism

#Woltmans #sign #PhysicalExam
Woltman’s sign on ... #Woltmans #sign ... PhysicalExam #clinical #video ... hypothyroidism #endocrinology ... #ankle #reflex