116 results
Gitelman Syndrome Overview

What?
• Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter
• Gitelman's syndrome
• Hypokalemia (renal ... Hypochloremic metabolic ... Sjögren syndrome, Renal ... Syndrome #diagnosis #nephrology ... #management #pathophysiology
Localization of Renal Tubular Defects
Fanconi Syndrome: Proximal tubule
Bartter Syndrome: Thick ascending loop of Henle
Gitelman Syndrome: Distal
Localization of Renal ... loop of Henle Gitelman ... Fanconi #Bartter #Gitelman ... Nephron #Defects #Pathophysiology ... #Nephrology
Gitelman Syndrome Pathophysiology
Gitelman Syndrome is a rare autosomal recessive salt-losing tubulopathy with a prevalence of 1-
Gitelman Syndrome ... Pathophysiology ... → Hypokalemia Metabolic ... #Syndrome #Pathophysiology ... #nephrology #diagnosis
Hypokalemia - Differential Diagnosis Algorithm
Extra-renal Losses:
 • Normal Acid-Base: Low intake
 • Metabolic acidosis: Gl tract
Algorithm Extra-renal ... Low intake • Metabolic ... loss (Diarrhea) Renal ... Bartter syndrome, Gitelman ... potassium #low #nephrology
Primary Metabolic Alkalosis - Differential Diagnosis Algorithm
Volume Depleted 2° hyperaldosteronism
 • Low Urine Cl-: Vomiting, NGT
Primary Metabolic ... Bartter Syndrome, Gitelman ... hyperaldosteronism • High PRA: Renal ... syndrome #Primary #Metabolic ... Diagnosis #Algorithm #nephrology
Primary Metabolic Alkalosis - Differential Diagnosis Algorithm
Volume Depleted - 2° hyperaldosteronism
 • Low Urine Cl-: Vomiting,
Primary Metabolic ... Bartter Syndrome, Gitelman ... hyperaldosteronism • High PRA: Renal ... aldosteronism #Metabolic ... Diagnosis #Algorithm #Nephrology
High Anion Gap Metabolic Acidosis (HAGMA) - Differential Diagnosis - GOLDMARK

Glycols - ethylene and propylene glycol
Oxoproline
High Anion Gap Metabolic ... during hypoxic metabolism ... ketoacidosis Renal ... acids in advanced renal ... GOLDMARK #mnemonic #nephrology
Hypomagnesemia - Differential Diagnosis
Renal Causes of Hypomagnesemia - Familial:
Bartter syndrome and Gitelman syndrome, Isolated recessive hypomagnesemia,
Differential Diagnosis Renal ... Bartter syndrome and Gitelman ... hypomagnesemia Renal ... Hypercalcemia, Post renal ... diagnosis #causes #nephrology
Renal osteodystrophy: Pathogenesis and radiological features.

#Renal #Osteodystrophy #Pathophysiology #Nephrology
Renal osteodystrophy ... #Renal #Osteodystrophy ... #Pathophysiology ... #Nephrology
Renal Tubular Disorders

 • Distal Renal Tubular Acidosis (Type 1)
 • Proximal Renal Tubular Acidosis (Type
Renal Tubular Disorders ... • Distal Renal ... ) • Proximal Renal ... Acidosis #Types #pathophysiology ... #nephrology #diagnosis