9 results
Growth Hormone Excess - Pathogenesis and clinical findings
 • Acromegaly and gigantism share the same pathophysiology
clinical findings • Acromegaly ... share the same pathophysiology ... Overproduction #diagnosis #signs ... #symptoms #endocrinology ... #pathophysiology
Feedback Loop: Growth Hormone (GH)
Growth Hormone:
 • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
activates lipolysis Signs ... - Giantism or acromegaly ... thickness) - metabolic ... #FeedbackLoop #endocrinology ... #pathophysiology
Acromegaly - Diagnosis and Management Summary - GrepMed Handbook 

Clinical Presentation: 
 • Classic Acromegaly: frontal
Acromegaly - Diagnosis ... Hypogonad (50%) • Metabolic ... malignancy Pathophysiology ... Diagnosis #Management #Endocrinology ... #Treatment #Pathophysiology
Woltman’s sign on Physical Exam

53-year-old man presented with fatigue and sensitivity to cold. A physical examination
Woltman’s sign on ... Woltman’s sign, ... #Woltmans #Signs ... Delayed #Clinical #Video ... #Neurology #Endocrinology
Hypothyroid Myopathy
Very common (up to 80% ) in patients with hypothyroidism
Pathophysiology:
 • T4 deficiency leads to
hypothyroidism Pathophysiology ... mitochondrial oxidative metabolism ... Hypothyroid #Myopathy #pathophysiology ... #signs #symptoms ... #endocrinology
Hypochloremia - Differential Diagnosis Algorithm

Cause - Decreased Intake:
 • Low salt in diet
 • Exclusive D5W
Excessive vomiting - Metabolic ... - Gitelman SIGNS ... increase may cause metabolic ... Diagnosis #Algorithm #Pathophysiology ... #Nephrology #Chloride
Diabetic Ketoacidosis (DKA) - Pathogenesis and Clinical Findings
 • Note: in DKA, body K+ is lost
Due to neuronal metabolism ... Signs/Symptoms/Complications ... DiabeticKetoacidosis #DKA #pathophysiology ... #endocrinology
Causes of Secondary Hypertension - Workup and Differential Diagnosis
Approach (when evaluation should be done):
1. Severe or
hypertension and signs ... hypokalemia and metabolic ... renal bruit or signs ... Vasculitis • Endocrinologic ... Cushing's syndrome, Acromegaly
Intact Corneomandibular (Wartenberg) Reflex

Patient with pontine hemorrhage without impaired consciousness - Left corneal stimulation triggers contralateral
structural from metabolic ... emphasize that this sign ... PhysicalExam #clinical #Neurology ... #Video #Wartenberg