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diagnosis differential liver algorithm management abnormal aflp alkaline arterial biliary cholangitis cirrhosis embolism enzymes fatty gap globulin hepatitis hyophosphatasia injury
Acute Fatty Liver of Pregnancy (AFLP) Pathophysiology: • Defect in fetal free fatty acid metabolism products →
) Pathophysiology ... free fatty acid metabolism ... Intermediate fatty acid metabolism ... = nonspecific (nausea ... Liver #Pregnancy #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Algorithm Vascular Causes ... vein: Budd-chiari syndrome ... Shock liver • Metabolic ... • Gilbert's syndrome ... diagnosis #algorithm #hepatology
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
65 years PBC Pathophysiology ... intralobular bile ducts causes ... failure PBC Signs ... cholangitis #diagnosis #workup ... #hepatology
Low Alkaline Phosphatase - Hypophosphatasia Is Low Alkaline Phosphatase Of Clinical Importance? ALP enzyme- Discovered in 1923 Low
Most cases diagnosed ... collection with EDTA Pathophysiology ... Nephrolithiasis • Metabolic ... Phosphatase: • Other causes ... Hyophosphatasia #hepatology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... high WBC count cause ... WBC >100k, + lab signs ... : • Pathophysiology ... diagnosis #management #hematology
Abnormal liver function tests algorithm. This figure details the initial response to abnormal liver blood tests.
clinical symptoms/signs ... The presence of metabolic ... syndrome criteria ... ALP, alkaline phosphatase ... Abnormal #Algorithm #Hepatology
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
• Nephrotic Syndrome ... considered in all ... coagulation and other causes ... Venous #Arterial #pathophysiology ... #hematology #differential
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
group of disorders caused ... formed or don’t work ... involve one, two, or all ... Workup: • Complete ... #diagnosis #hematology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Albumin > 4) Work-up ... changes (POEMS syndrome ... Castleman disease • AL ... gastric tumors • Hematology ... differential #diagnosis #hematology
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