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diagnosis differential causes algorithm ascites injury management coagulation lfts saag transaminitis albumin arterial biliary chemistry cholangitis chronic comparison deficiencies deficiency
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... those with CLD (± cirrhosis ... Hepatitis (AAH) Drug-Induced ... #Acute #Chronic ... #Cirrhosis #Hepatology
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
• NAFLD • Cirrhosis ... Hepatopathy • Acute ... 1000): • DILI (Drug-induced ... ) • Non-hepatic ... Differential #Diagnosis #hepatology
Causes of Portal Hypertension According to Site of Vascular Obstruction 1) Prehepatic pre-sinusoidal: Portal vein thrombosis due
or secondary to cirrhosis ... fibrosis, Drugs ... 3) Sinusoidal: Cirrhosis ... , Polycystic liver ... diagnosis #causes #hepatology
Portal Hypertension - Differential Diagnosis Portal Pressure = the pressure difference between the pressure in the portal
Clues to non-cirrhotic ... /acute hepatitis ... sarcoidosis) • Liver ... metastasis • Fatty liver ... Diagnosis #causes #hepatology
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
Causes of Acute ... , Recreational Drugs ... Vasculature • Hepatic ... Congestion/CHF • Hepatic ... #algorithm #hepatology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Drug Induced Liver ... disease, Hepatic ... dechallenge • Acute ... presentation: Hepatic ... Diagnosis #Algorithm #hepatology
Summary of Coagulation Deficiencies Inherited: • Hemophilia A - Deficiency of Factor VIII • Hemophilia B -
Medications - Heparin ... ) • Advanced Liver ... catastrophes, Acute ... Deficiencies #Summary #table ... comparison #diagnosis #hematology
Causes of Ascites - Differential Diagnosis Algorithm Portal Hypertension - Prehepatic: • Portal vein thrombosis • Splenic
Hypertension - Hepatic ... : • Cirrhosis ... Infiltrative disease • Acute ... liver failure ... Diagnosis #Algorithm #Hepatology
Causes of Ascites Normal Peritoneum Portal hypertension (SAAG > 1.1 g/dL) 1. Hepatic congestionl
Liver disease ... - Cirrhosis ... fibrosis - Acute ... fatty liver of ... #differential #hepatology
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
65 years PBC Pathophysiology ... /Liver failure ... malignancies, Hepatic ... , Sarcoidosis, Drug-induced ... diagnosis #workup #hepatology
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