9 results
Characteristic clinical manifestations of Down syndrome 
 
Typical craniofacial appearance 
 • Round face and flat
• Brushfield spots ... iris (pigmented spots ... neck • Single ... #PhysicalExam # ... Features #Signs
Behçet's Syndrome
Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy
Epidemiology:
 • Young
ulceration • Ocular ... white matter, spinal ... Oral aphthae : SLE ... • Arthritis: SLE ... signs #symptoms #rheumatology
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Erythematous, macular ... Non-autoimmune rheumatologic ... Clinical Features ... • Malar rash - spares ... Erythematosus #Diagnosis #Rheumatology
Facial Swelling - Differential Diagnosis Framework for Facial Edema

Infectious:
	• Dental abscess
	• Ludwig's angina
	• Vincent's angina
	• Cellulitis
	•
Autoimmune: • SLE ... Adult-onset Still's disease ... Trauma: • Ocular ... : • Morbihan disease ... Differential #Diagnosis #PhysicalExam
Vasculitis Involving the Skin - Differential Diagnosis Framework

Primary: 50% Cutaneous Vasculitis: Leukocytoclastic Vasculitis
Secondary: CTD: SLE, RA
Secondary: CTD: SLE ... GPA Cutaneous Single ... Vasculitis: • Behcet Disease ... • Cogan syndrome ... #dermatology #rheumatology
SAPHO Syndrome Summary

What?
SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
pain Clinical Features ... skeleton-sacroiliac joint and spine ... sites such as the collar ... osteoarticular and skin disease ... #Rheumatology #
Sjogren's Syndrome Overview

Epidemiology:
• F > M: 9:1
• 5-6th Decades (can be any age)

Autoimmune exocrinopathy multisystemic disease
Sjogren's Syndrome ... overlaps with RA, SLE ... gland) biopsy • Ocular ... ducts Clinical Features ... #Rheumatology #
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Pinpoint-sized red spots ... Myeloproliferative Disease ... with single-lineage ... characteristic feature ... #diagnosis #hematology
Relapsing Polychondritis

What is it?
Recurrent inflammation of the cartilage in the body (Autoimmune disorder)

Who?
• Most frequently: 40
chondritis • Ocular ... immunologically mediated diseases ... cases such as: • SLE ... Sarcoidosis • Behcet disease ... Polychondritis #rheumatology