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management druginduced hematology hemophagocytic hlh lymphohistiocytosis activation comparison differential dil disease erythematosus hemeonc macrophage mas myelitis neurology onset stills summary
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
Prognosis: Usually mild ... constitutional symptoms • Treatment ... life-threatening • Treatment ... #table #rheumatology ... #diagnosis #management
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
-1 and IL-6, leading ... erythematosus [SLE ... ], AOSD) • Infection ... Histopathologic criteria ... #Rheumatology
Adult Onset Still's Disease Systemic inflammation with urticarial rash. Rash: • Nonpruritic, evanescent (correlates with time of
Adult Onset Still's ... should be major: 1. ... Treatment - Mild ... Stills #disease #AOSD ... #diagnosis #rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... rheumatoid arthritis, adult-onset ... pneumonitis • ... • ANA titers > 1: ... #Rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH) Pathophysiology ... cytokines (TNFa,lL1, IL6 ... Autoimmune diseases: SLE ... +++, Adult-onset ... #summary #rheumatology
Drug Induced Lupus (DIL) • Epidemiology: -10% of all lupus cases, drug-dependent, 4:1 to 1:1 F:M
to 1:1 F:M • Clinical ... is rare in DIL, SCLE-DIL ... Prognosis: Usually mild ... #DIL #rheumatology ... #diagnosis #treatment
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
monophasic Pathophysiology ... varying degrees of: 1. ... Criteria: • Sensory ... Disorders: - SLE ... Transverse Myelitis Treatment
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
dysfunction. 1. ... to find in an adult ... - Common in: Adults ... Pathophysiology ... Diagnostic Criteria
TAFRO TAFRO syndrome was first described in 2010, standing for: - Thrombocytopenia - Anasarca - Fever - Reticulin fibrosis - Organomegaly TAFRO syndrome
including systemic lupus ... erythematosus (SLE ... cell lymphoma Pathophysiology ... Hypoalbuminemia Treatment ... #management #rheumatology
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