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management cppd hematology activation apml calcium cancer comparison deposition differential differentiation disease erythematosus gout hyponatremia lupus macrophage mas nephrology pseudogout
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Macrophage Activation Syndrome ... -1 and IL-6, leading ... Histopathologic criteria ... #Diagnosis #Management ... #Hematology #Rheumatology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... ATRA treatment Pathophysiology ... symptoms, or> 1 ... #management #hematology ... #oncology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Differential Diagnosis ... • Acute lupus pneumonitis ... • ANA titers > 1: ... Ro/La, anti-Jo-1, ... #Rheumatology
CPPD vs Gout == CPPD == Think About CPPD When: • Self-limited synovitis after surgery/trauma (> 65
trauma (> 65 years old ... disease states Pathophysiology ... • Metabolic syndrome ... Gout #Comparison #rheumatology ... #Diagnosis
Hyponatremia Differential Diagnosis Algorithm in Cancer UOsm ≥ 100 mOsm/kg = Urine is inappropriately concentrated for hypotonic
Algorithm in Cancer ... losses, CAR-T- and IL ... capillary leak syndrome ... adrenalitis; PD-1 ... #nephrology #oncology
Pseudogout Summary - Calcium Pyrophosphate Deposition Disease (CPPD) Pathophysiology: Pyrophosphate produced by chondrocytes likely precipitates with calcium to
Disease (CPPD) Pathophysiology ... trauma (> 65 years old ... disease states 1. ... Crowned Dens Syndrome ... Deposition #Disease #Rheumatology
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