22 results
Connective tissue disease-associated interstitial lung diseases

LIP: lymphoid interstitial pneumonia. NSIP: nonspecific interstitial pneumonia. OP: organizing pneumonia.
interstitial lung diseases ... DM/PM : dermatomyositis ... ConnectiveTissueDiseases #ILD ... Differential #Comparison #Table ... #Pulmonary #Rheumatology
Autoantibodies and their Disease Associations
ANA - Non-specific; common in SLE, autoimmune hepatitis
Anti-CCP, Rheumatoid factor - RA
Anti-dsDNA
Autoantibodies and their Disease ... Drug-induced SLE Anti-Jo-1 ... Polymyositis / Dermatomyositis ... #diagnosis #table ... #rheumatology #
On the left some diseases with a nodular pattern.
1. Hypersensitivity pneumonitis: ill defined centrilobular nodules.
2. Miliary
the left some diseases ... nodular pattern. 1. ... Hypersensitivity pneumonitis ... Hypersensitivity pneumonitis ... Differential #Comparison #Table
Inflammatory Myopathies
Dermatomyositis
 • Onset: Subacute
 • Pattern: Proximal
 • CK: Up to 50X ULN
 • Autoantibodies:
Inflammatory Myopathies ... Dermatomyositis ... anti-Mi-2, anti-TIF-1, ... diagnosis #comparison #rheumatology ... #table
ANTI-MDA5 DERMATOMYOSITIS

Cutaneous manifestations:
• Periorbital heliotrope (blue-purple) rash with edema
• Erythematous rash on the face, or the
severity of the disease ... and ILD • Liver ... increases and ILD ... Phenotype 1 ... #rheumatology #
Approach to Joint Pain - Arthritis Differential Diagnosis Framework

Inflammatory Versus Noninflammatory Pain
 • Is it inflammatory
lasting > 30 mins - 1 ... - Autoimmune Rheumatologic ... Disease OLIGOARTHRITIS ... Ankylosing Spondylitis, IBD ... Diagnosis #MSK #rheumatology
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
background of a highly inflammatory ... disease How? ... release of pro-inflammatory ... -1 and IL-6, leading ... #Rheumatology
Distinguishing between Inflammatory and Degenerative joint disease
Inflammatory Joint Disease
 • Swelling stimulates joint nociceptors -> Pain
Degenerative joint disease ... Disease • Swelling ... resolves after > 1 ... cartilage triggers a mild ... JointPain #Diagnosis #pathophysiology
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
photosensitivity, inflammatory ... , dermatomyositis ... • Acute lupus pneumonitis ... • ANA titers > 1: ... Ro/La, anti-Jo-1,
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH) Pathophysiology ... production of pro-inflammatory ... cytokines (TNFa,lL1, IL6 ... • Autoimmune diseases ... treatment #summary #rheumatology