15 results
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
• Immunologic Workup ... Prognosis: Usually mild ... Discontinuation of causal ... • Immunologic Workup ... #diagnosis #management
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary
 • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
of SLE versus DIL ... • Immunologic Workup ... Positive in 60-80% of cases ... of SLE • Evolution ... #Summary #rheumatology
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
cytokines, such as IL ... -1 and IL-6, leading ... manifestations: from easy bruising ... Increased soluble IL ... #Diagnosis #Management
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework

== Quantitative or Qualitative defect in
Bleeding and Bruising ... von Willebrand syndrome ... Acquired: • Mild ... discern these causes ... Differential #Diagnosis #Hematology
Acute Pancreatitis - Diagnosis and Management - GrepMed Handbook

Presentation: 
 • Epigastric abdominal pain (90%, characteristically
(Grey-Turner) bruising ... Imaging findings Workup ... Triglycerides (>1000 mg/dL ... Imaging: US (biliary evaluation ... low-fat (as safe as CLD
SAPHO Syndrome Summary

What?
SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
Rule out other causes ... efficacious include IL ... -1 inhibitors, IL ... inhibitors, and IL ... diagnosis #management
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... Easy or unusual bruising ... with isolated del ... Workup: • Complete ... #diagnosis #hematology
Cardiac Arrest - Guidelines for Crises in Anaesthesia

The probable cause is one or more of: something
senior on-call / dial ... delegate task of evaluating ... #Differential #Anesthesiology ... Checklist #Diagnosis #Management ... #Workup
Drug Induced Lupus (DIL)
 • Epidemiology: -10% of all lupus cases, drug-dependent, 4:1 to 1:1 F:M
• Immunologic Workup ... Discontinuation of causal ... • Evolution: ... #rheumatology # ... diagnosis #treatment #management
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
cytokines (TNFa,lL1, IL6 ... Fibrinogen level, ↑ sIL ... Drugs, Unknown cause ... inhibitors under evaluation ... Lymphohistiocytosis #diagnosis #management