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coagulation diagnosis causes differential heparin ptt warfarin abnormal anticoagulation apaxiban aptt bleeding bruising clot coumadin dabigatran dic disseminated doac edoxaban
Coagulation cascade and anticoagulants Satyendra Dhar MD, @DharSaty #coagulation #coumadin #heparin #warfarin #apaxiban #pradaxa #xarelto #DOAC #vWF
Coagulation cascade ... and anticoagulants ... heparin #warfarin #apaxiban ... xarelto #DOAC #vWF #thrombin ... #ptt #pt
The coagulation cascade is shown, separated into different phases with their endogenous and pharmacological inhibitors shown.
FVa to generate thrombin ... Thrombin, then primes ... large amounts of thrombin ... #platelet #thrombin ... #clot #PT #PTT
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
integrity Clotting cascade ... deficiency • Anticoagulants ... warfarin, direct thrombin ... deficiency • Anticoagulant ... Differential #Diagnosis #Hematology
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Causes of Abnormal PT ... - Rivaroxaban, apixaban ... heparin - Other anticoagulants ... drugs e.g. direct thrombin ... #differential #hematology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
• Prolonged PT ... • Increased thrombin ... Fibrinogen: ↓ • PT ... Reduction of pro/anticoagulants ... treatment #management #hematology
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