5 results
Coagulation cascade and anticoagulants 

Satyendra Dhar MD, @DharSaty

#coagulation #coumadin #heparin #warfarin #apaxiban #pradaxa #xarelto #DOAC #vWF
Coagulation cascade ... #coumadin #heparin ... #warfarin #apaxiban ... xarelto #DOAC #vWF #thrombin ... #ptt #pt
The coagulation cascade is shown, separated into different phases with their endogenous and pharmacological inhibitors shown.
#Coagulation #Cascade ... #clot #PT #PTT ... diagnosis #models #hematology ... #inhibitor #Apixaban ... Rivaroxaban #Edoxaban #heparin
Causes of Abnormal PT and/or aPTT
Prolonged Prothrombin Time (PT)
1. Acquired deficiency of FVII
- Rivaroxaban, apixaban ... unfractionated heparin ... drugs e.g. direct thrombin ... #differential #hematology ... #coagulation
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
• Prolonged PT ... • Increased thrombin ... Fibrinogen: ↓ • PT ... Schistocytes, helmet cells ... treatment #management #hematology
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework

== Quantitative or Qualitative defect in
inhibitor of a coagulation ... integrity Clotting cascade ... Acquired: • Heparin ... warfarin, direct thrombin ... Differential #Diagnosis #Hematology