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diagnosis blood coagulation product reactions syndrome treatment anticoagulant anticoagulation apixaban ascites cascade causes chemistry clot dabigatran dic differential disseminated edoxaban
The coagulation cascade is shown, separated into different phases with their endogenous and pharmacological inhibitors shown.
FVa to generate thrombin ... Thrombin, then primes ... and endothelial cells ... #clot #PT #PTT ... diagnosis #models #hematology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
• Prolonged PT ... • Increased thrombin ... Fibrinogen: ↓ • PT ... causes #treatment #management ... #hematology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Lysis of tumor cells ... lethargy, hematuria, cardiac ... with tetany or cardiac ... TLS #diagnosis #management ... #hematology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Coagulation factors: PT ... Skeletal muscle, cardiac ... Skeletal muscle, Cardiac ... intestines, White blood cells ... #differential #Hepatology
Hepatopulmonary Syndrome - Diagnosis and Management Summary A defect in arterial oxygenation due to a gas exchange
Diagnosis and Management ... left heart 3-6 cardiac ... Arterial blood gas (ABC ... SpO2 > 88% • Management ... #treatment #hepatology
Ascites - Diagnosis and Management Summary Paracentesis studies: cell count + differential, albumin, protein, culture • Serum-ascites-albumin-gradient
Diagnosis and Management ... x PMN%) > 250 cells ... g/dL, consider cardiac ... Ascites #Diagnosis #Management ... #Summary #Hepatology
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
• Transfusion Cardiac ... potassium from lysed cells ... RBCs (stored at 4C ... Transfusion #diagnosis #management ... #hematology #reactions
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
- Transfusion Cardiac ... potassium from lysed cells ... RBCs (stored at 4C ... Transfusions #diagnosis #management ... #hematology #reactions
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