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diagnosis hematology causes abnormal aptt prolonged anticoagulation apixaban bleeding bruising cascade clot dabigatran dic edoxaban hemostasis heparin inhibitor intravascular management
The coagulation cascade is shown, separated into different phases with their endogenous and pharmacological inhibitors shown.
The coagulation ... and endothelial cells ... #Coagulation #Cascade ... #clot #PT #PTT ... anticoagulation #anticoagulant
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Disseminated Intravascular ... • Prolonged PT ... • Increased thrombin ... Fibrinogen: ↓ • PT ... Reduction of pro/anticoagulants
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
heparin - Other anticoagulants ... drugs e.g. direct thrombin ... Disseminated intravascular ... coagulation (DIC ... Causes #diagnosis #differential
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
of Hemostasis - Differential ... inhibitor of a coagulation ... liver failure, disseminated ... intravascular coagulation ... warfarin, direct thrombin
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
Differential Diagnosis ... drugs (e.g. direct thrombin ... hemorrhage • Disseminated ... Causes #diagnosis #differential ... #hematology #coagulation
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