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diagnosis hematology causes abnormal aptt prolonged blanching bruise bruising chemistry dic ecchymosis hematomas hemostasis hepatology interpretation intravascular lfts liver management
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Disseminated Intravascular ... • Prolonged PT ... • Increased thrombin ... Fibrinogen: ↓ • PT ... #DIC #Disseminated
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
of Hemostasis - Differential ... inhibitor of a coagulation ... liver failure, disseminated ... intravascular coagulation ... warfarin, direct thrombin
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
drugs e.g. direct thrombin ... Disseminated intravascular ... coagulation (DIC ... Causes #diagnosis #differential ... #hematology #coagulation
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
Differential Diagnosis ... drugs (e.g. direct thrombin ... hemorrhage • Disseminated ... Causes #diagnosis #differential ... #hematology #coagulation
Bleeding manifestations Petechiae are small, flat, red, discrete areas of skin bleeding that are typically <2
are typical of coagulation ... in endothelial cells ... to be normal, PT ... Measurement of coagulation ... VWF:RCo/VWF:Ag (differentiate
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
• Albumin • Coagulation ... factors: PT/INR ... RBC (hemolysis, bleeding ... intestines, White blood cells ... chemistry #diagnosis #differential
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