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diagnosis hematology algorithm aptt petechiae prolonged blanching bleeding bruise bruising dermatology dic ecchymosis hematomas hemostasis intravascular management obgyn obstetrics petechial
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
drugs (e.g. direct thrombin ... • Massive hemorrhage ... • Disseminated ... amyloidosis #Abnormal ... hematology #coagulation
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Causes of Abnormal ... drugs e.g. direct thrombin ... Massive hemorrhage ... Disseminated intravascular ... #differential #
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Disseminated Intravascular ... • Prolonged PT ... • Increased thrombin ... Acral cyanosis • Hemorrhagic ... Fibrinogen: ↓ • PT
Causes of Post-Partum Hemorrhage - Differential Diagnosis Algorithm Blood Loss: >500mL post vaginal delivery OR >1000 mL
Causes of Post-Partum ... Hemorrhage - Differential ... succenturiate lobe • Abnormal ... or percreta) Thrombin ... HELLP syndrome • Disseminated
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
PT/NORMAL PTT: ... PT/ABNORMAL PTT ... PT/NORMAL PTT: ... PT/ABNORMAL PTT ... discern these causes
Causes of Petechial Rash - Differential Diagnosis Algorithm Pinpoint areas (less than 2 mm) of hemorrhage, which
Causes of Petechial ... Rash - Differential ... than 2 mm) of hemorrhage ... Meningococcemia - Disseminated ... Complete blood count coagulation
Bleeding manifestations Petechiae are small, flat, red, discrete areas of skin bleeding that are typically <2
ecchymosis) is caused ... are typical of coagulation ... in endothelial cells ... , PT should be normal ... VWF:RCo/VWF:Ag (differentiate
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