6 results
Causes of Abnormal PT and/or aPTT
Prolonged Prothrombin Time (PT)
1. Acquired deficiency of FVII
drugs e.g. direct thrombin ... Disseminated intravascular ... coagulation (DIC ... Causes #diagnosis #differential ... #hematology #coagulation
Differential Diagnosis for a Prolonged PT and aPTT
If the PT and the aPTT are both prolonged,
Differential Diagnosis ... drugs (e.g. direct thrombin ... hemorrhage • Disseminated ... Causes #diagnosis #differential ... #hematology #coagulation
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
Disseminated Intravascular ... Thrombocytopenia • Prolonged ... PT/PTT • Low ... • Increased thrombin ... Fibrinogen: ↓ • PT
Causes of Post-Partum Hemorrhage - Differential Diagnosis Algorithm
Blood Loss: >500mL post vaginal delivery OR >1000 mL
Post-Partum Hemorrhage - Differential ... fatigue (e.g. prolonged ... or percreta) Thrombin ... HELLP syndrome • Disseminated ... intravascular coagulation
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework

== Quantitative or Qualitative defect in
of Hemostasis - Differential ... inhibitor of a coagulation ... prolonged after ... liver failure, disseminated ... warfarin, direct thrombin
Bleeding manifestations 
Petechiae are small, flat, red, discrete areas of skin bleeding that are typically <2
are typical of coagulation ... in endothelial cells ... Excessive bruising & prolonged ... to be normal, PT ... VWF:RCo/VWF:Ag (differentiate