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diagnosis hematology causes abnormal anticoagulation aptt cascade clot dabigatran differential disseminated edoxaban heparin inhibitor intravascular management models pathophysiology pathway platelet
The coagulation cascade is shown, separated into different phases with their endogenous and pharmacological inhibitors shown.
The coagulation ... along with FXIIa (intrinsic ... #clot #PT #PTT ... anticoagulation #anticoagulant ... #inhibitor #Apixaban
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
• Prolonged PT ... • Increased thrombin ... Fibrinogen: ↓ • PT ... significant fibrin clot ... Reduction of pro/anticoagulants
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
- Rivaroxaban, apixaban ... heparin - Other anticoagulants ... Congenital intrinsic ... drugs e.g. direct thrombin ... (DIC) c.
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