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diagnosis management rheumatology dermatology hlh lymphohistiocytosis activation differential dress endocarditis infectiousdiseases mas oncology polychondritis relapsing summary sweet
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
A subset of hemophagocytic ... • Periodic fever ... - Nonremitting fever ... Treatment: • Corticosteroids ... Diagnosis #Management #Hematology
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Overwhelming clinical syndrome ... with excessive macrophage ... age, however the disease ... following: • Fever ... #hematology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Hemophagocytic Lymphohistiocytosis ... activation of macrophages ... • Clinical: fever ... • Autoimmune diseases ... Treatment: •
Sweet Syndrome Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
characterized by fever ... with systemic disease ... Causes: - Idiopathic ... , breast CA - Hematologic ... Treatment: - Systemic
Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Definition: • Severe adverse drug reaction, characterized by
Edema in 70% of cases ... Fever >38.5 2. ... : symptomatic treatment ... • Severe disease ... SinaiBmoreIMRes #DRESS #Syndrome
Endocarditis - Overview and Differential Diagnosis Framework Who? Infectious: • Pre-existing valvular disease • Prosthetic valve • Congenital heart disease • IV
night sweats, fever ... Cholesterol emboli syndrome ... Septic emboli cause ... hematuria, + RF Treatment ... Differential #Diagnosis #cardiology
Relapsing Polychondritis What is it? Recurrent inflammation of the cartilage in the body (Autoimmune disorder) Who? • Most frequently: 40
Nonspecific symptoms: Fever ... immunologically mediated diseases ... Sarcoidosis • Behcet disease ... affected tissue Treatment ... Polychondritis #rheumatology
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