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differential hematology management vasculitis classification clinical encephalopathy gap globulin hus lichen microangiopathy myopathy myositis neurology photo planus posterior pres protein
Thrombotic Microangiopathy - TMAs 1. Not all MAHAs are due to TMAs but (almost) all TMAs cause
almost) all TMAs cause ... TMA is a triad of ... /o significant renal ... . 5. 2nd TMA- autoimmune ... #diagnosis #ttp
Pulmonary Renal Syndromes - OnePager Summary Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
OnePager Summary Autoimmune ... antibody, Anti-GBM ... Goodpasture's cause ... blood retum in serial ... hematuria, RBC casts
Lichen Planus- ...On examination, numerous purple papules were noted on the anterior surface of the forearms
sawtooth rete pegs ... confirming the diagnosis ... thought to be an autoimmune ... #NEJM #clinical ... lichen #planus #derm
Posterior Reversible Encephalopathy Syndrome (PRES) Overview Clinico-Radiological Syndrome, characterized by: • Headache • Seizures • Altered mental
/Sepsis/Shock, Autoimmune ... Constipation, Seizures, Stroke ... the underlying cause ... Seizures: Treat with AEDs ... until cause identified
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
- Differential Diagnosis ... tract, and often causes ... glomerulonephritis) • Anti-GBM ... mucositis - Rash ... #rheumatology #
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
pulmonary and renal ... carotodynia • TIA, stroke ... , mucositis • Rash ... tract, and often causes ... #Rheumatology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
acute HIV, HBV, EBV ... Cirrhosis, ETOH, autoimmune ... cancers, HCC, renal ... #differential #diagnosis ... #hematology
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
RP-ILD), dermato-rheumatologic ... Symptoms: • Gottron rash ... • ANA < 20 % IBM ... esophagus upper 2/3 striated ... statins - probably caused
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