11 results
Plain radiography of the abdomen revealed calcification of both adrenal glands. A homozygous mutation in LIPA
confirmed the diagnosis ... deficiency, or Wolman’s disease ... and gut, which causes ... #clincial #peds ... #infant #NEJM #
IgG4-Related Disease
Clinical history:  Man, 60 years, multiorgan involvement, unique or multiple inflammatory pseudotumor
4 phenotypes:
 •
IgG4-Related Disease ... Clinical history ... aorta, salivary glands ... hypergammaglobulinemia, ↑ acute ... supporting long-term
Lichen Planus- ...On examination, numerous purple papules were noted on the anterior surface of the forearms
confirming the diagnosis ... Although the cause ... an autoimmune disease ... #NEJM #clinical ... #derm #wickhams
Syphilis - Clinical Manifestations and Treatment

1) Primary Syphilis
 • Direct lesion contact during sex is responsible
Syphilis - Clinical ... loss • Skin: Rash ... Albuminuria, nephrotic syndrome ... , or acute nephritis ... Syphilis #stages #diagnosis
Posterior Reversible Encephalopathy Syndrome (PRES) Overview

Clinico-Radiological Syndrome, characterized by:
 • Headache
 • Seizures
 • Altered mental
Shock, Autoimmune disease ... , ADEM, Acute toxic ... the underlying cause ... • Treatment of ... until cause identified
Acute Retroviral Syndrome
Acute Retroviral Syndrome is the symptomatic presentation of acute human immunodeficiency virus infection

 •
Syndrome Acute ... (28%) • Skin rash ... Epstein-Barr virus (EBV ... antibody test) Treatment ... ART to slow HIV disease
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis

The most common causes of hyperlactatemia are usually:
presentations and disease ... before beginning treatment ... cardiac output - Acute ... - Compartment syndrome ... peritonitis - Acute
The Stages of Syphilis 

Primary Syphilis 
- The chancre lesion is the hallmark of primary syphilis.
Without treatment ... Syphilis - Rash ... manifestations including acute ... Latent #Tertiary #Diagnosis ... of Infectious Diseases
Sjogren's Syndrome Overview

Epidemiology:
• F > M: 9:1
• 5-6th Decades (can be any age)

Autoimmune exocrinopathy multisystemic disease
salivary and lacrimal glands ... Diagnosis: • Dry ... Hypocomplementemia • Can cause ... salivary ducts Clinical ... Adenocarcinoma Treatment
Hepatorenal Syndrome (HRS)

Definition:
• Functional, potentially reversible kidney impairment.
• Occurs in advanced liver disease: cirrhosis, severe alcoholic
Hepatorenal Syndrome ... advanced liver disease ... hepatitis, or acute ... Diagnosis (Clinical ... Treatment Overview