11 results
ANTI-MDA5 DERMATOMYOSITIS

Cutaneous manifestations:
• Periorbital heliotrope (blue-purple) rash with edema
• Erythematous rash on the face, or the
ANTI-MDA5 DERMATOMYOSITIS ... (blue-purple) rash ... • Erythematous rash ... Men • ~50% of cases ... #rheumatology #
Plain radiography of the abdomen revealed calcification of both adrenal glands. A homozygous mutation in LIPA
calcification of both adrenal ... and gut, which causes ... #clincial #peds ... #adrenal #calcifications ... #infant #NEJM #
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies)
 • Systemic lupus erythematosus
   1. Anti-dsDNA
Anti-dsDNA (in 70% of cases ... seen in 30—70% of cases ... Polymyositis and dermatomyositis ... polyangiitis without renal ... antibodies #diagnosis #rheumatology
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
evidence of (fatigue, rash ... Still disease, dermatomyositis ... Non-autoimmune rheumatologic ... APLA/LAC: • Renal ... Erythematosus #Diagnosis #Rheumatology
Anti-NXP-2 Dermatomyositis

What?
DM with generalized subcutaneous edema
Pts have more myalgias, more severe weakness, and an increased prevalence
(blue-purple) rash ... • Erythematous rash ... Muscle atrophy may cause ... • Clear cell renal ... diagnosis #management #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
pulmonary and renal ... tract, and often causes ... mucositis - Rash ... • Urinalysis (Renal ... differential #diagnosis #rheumatology
Blood Transfusion Reactions

Immune Mediated:
 • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
, DIC, hypoTN, renal ... maculopapular rash ... Causes purpura & ... TRALI): Leading cause ... diagnosis #management #hematology
Blood Product Transfusions One Pager Summary
Type and screen - determines blood type and detects in recipient
, DIC, hypoTN, renal ... maculopapular rash ... Causes purpura & ... TRALI): Leading cause ... more likely to cause
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
pulmonary and renal ... , mucositis • Rash ... tract, and often causes ... Differential #Diagnosis #Rheumatology
Autoimmune Myositis - Differential Diagnosis Framework

Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
levels • EMG DERMATOMYOSITIS ... RP-ILD), dermato-rheumatologic ... Symptoms: • Gottron rash ... statins - probably caused ... Myositis #Myopathy #rheumatology