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diagnosis hematology hemophagocytic hlh lymphohistiocytosis crisis erythematosus hemeonc lupus nephrology renal scleroderma src summary syndrome systemic treatment
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Macrophage Activation ... nervous system (CNS ... Petechial or purpuric rash ... erythematosus [SLE ... #Macrophage #Activation
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
→Activation of CD8 ... of macrophages ... Autoimmune diseases: SLE ... Lymphohistiocytosis #diagnosis #management ... treatment #summary #rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
) Suspect: Clinical ... Non-autoimmune rheumatologic ... lymphoproliferative syndrome Clinical ... CNS • Headache ... Chronic B-cell activation
Scleroderma Renal Crisis (SRC) Clinical Presentation of Scleroderma Renal Crisis: 1) Acute kidney injury 2) Abrupt onset of hypertension 3)
Crisis (SRC) Clinical ... is unknown but may ... endothelial cell activation ... , add other BP meds ... Renal #Crisis #rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
hyperinflammatory syndrome caused ... (often termed MAS-HLH ... : Macrophage Activation ... Clinical Presentation ... #Hematology #HemeOnc
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