10 results
Clinical Features of Systemic Lupus (SLE)
General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%)
Eye: Sjögrens (15%)
Skin
Clinical Features ... Sjögrens (15%) Skin ... Photosensitivity, Butterfly rash ... Glomerulonephritis Myositis(5%) Blood ... symptoms #diagnosis #rheumatology
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA)

Skin involvement in granulomatosis with polyangiitis (GPA) is common and
GPA causes disease ... Rarely dominate the clinical ... Maculopapular rash ... vasculitis (inflamed blood ... #diagnosis #rheumatology
ANTI-MDA5 DERMATOMYOSITIS

Cutaneous manifestations:
• Periorbital heliotrope (blue-purple) rash with edema
• Erythematous rash on the face, or the
(blue-purple) rash ... • Erythematous rash ... auricular papules Clinical ... onset [33-74%] • Blood ... Dermatomyositis #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
tract, and often causes ... mucositis - Rash ... pulses, bruis, or blood ... Large Vessel: Blood ... differential #diagnosis #rheumatology
Blood Product Transfusions One Pager Summary
Type and screen - determines blood type and detects in recipient
, DIC, hypoTN, renal ... maculopapular rash ... Causes purpura & ... TRALI): Leading cause ... infections with skin
Blood Transfusion Reactions

Immune Mediated:
 • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
, DIC, hypoTN, renal ... maculopapular rash ... Causes purpura & ... TRALI): Leading cause ... infections with skin
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
pulmonary and renal ... pulses, bruits, or blood ... , mucositis • Rash ... tract, and often causes ... Differential #Diagnosis #Rheumatology
Sjogren's Syndrome Overview

Epidemiology:
• F > M: 9:1
• 5-6th Decades (can be any age)

Autoimmune exocrinopathy multisystemic disease
Lacrimal swelling • Skin ... Hypocomplementemia • Can cause ... salivary ducts Clinical ... effusion, INC risk PE ... Sjogrens #Syndrome #Rheumatology
Uremic Frost in End-Stage Renal Disease- A 39-year-old man with end-stage renal disease presented to the
with anorexia, nausea ... urine output...His skin ... studies showed a blood ... of urea on the skin ... #NEJM #clinical
Anti-NXP-2 Dermatomyositis

What?
DM with generalized subcutaneous edema
Pts have more myalgias, more severe weakness, and an increased prevalence
(blue-purple) rash ... • Erythematous rash ... auricular papules Clinical ... Muscle atrophy may cause ... diagnosis #management #rheumatology