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differential hematology management comparison hemophagocytic hlh hodgkins lymphohistiocytosis lymphoma oncology vasculitis compared ddxof dermatology em erythemas erythematosus hemeonc lupus myopathy
Erythemas Summarized Erythema ab igne • A dermatosis that results from repeated exposure to heat (fires, heating
fires, heating pads ... malignancies, autoimmune ... known as rat bite fever ... or Haverhill fever ... #differential #diagnosis
Serious Bacterial Illness (SBI): 1) UTI and pyelonephritis Most common cause of SBI Accounts for 3-8% of uncharacterized fevers Female
pyelonephritis Most common cause ... uncharacterized fevers ... unformed) PNA diagnosed ... #Peds #EM #Classification ... #Fever #SBI #SeriousBacterialIllness
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Auto-amplification loop Diagnosis ... • Clinical: fever ... solid cancers • Autoimmune ... Drugs, Unknown cause ... treatment #summary #rheumatology
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison Hodgkin's Lymphoma: • Epidemiology: young adults 20-30, older 50-70 •
., HIV), EBV infection ... , Autoimmune diseases ... - Pel-Ebstein fever ... Pylori) - Autoimmune ... translocation • Types: Classification
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
weight loss, and fever ... Skin Disease Classification ... Differential Diagnosis ... rheumatologic diseases ... #Rheumatology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
• History of EBV ... Immunosuppression • Autoimmune ... • Dyspnea • Fever ... ) Classification ... #classification
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
tract, and often causes ... mucositis - Rash ... Vasculitis: • Fevers ... #rheumatology # ... classification
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
- Differential Diagnosis ... , mucositis • Rash ... tract, and often causes ... pain and GN Anti-GBM ... #Rheumatology
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
RP-ILD), dermato-rheumatologic ... Symptoms: • Gottron rash ... Overlap Syndrome: Fever ... • ANA < 20 % IBM ... statins - probably caused
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
hyperinflammatory syndrome caused ... Infections (e.g., EBV ... Malignancies ▪ Autoimmune ... Infections, malignancy, autoimmune ... #Management #Hematology
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