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dermatology differential rheumatology druginduced management classification clinical complications dil manifestations mucocutaneous mucormycosis papulosquamous pathophysiology signs skin symptoms table treatment vasculitides
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
cases, drug-dependent ... Rare (SSA+ for cutaneous ... Positive in 60-80% of cases ... #sle #comparison ... #rheumatology #diagnosis
Vesiculobullous Skin Rash - Differential Diagnosis Algorithm Vesicles Fragile/EasiIy Ruptured - Intraepidermal blisters, possibly crusts/erosions - Inflammatory
Vesiculobullous Skin Rash ... Algorithm Vesicles ... Bullous systemic lupus ... Vesiculobullous #SkinRash ... #Algorithm #causes
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
Lupus (SLE): Mucocutaneous ... response -> Subacute cutaneous ... hair follicles -> causes ... Malar (butterfly) Rash ... pathophysiology #diagnosis
Cutaneous Mucormycosis Eschar 30 M HIV cd4 10 VL 30k traumatic injury of arm few months ago
Diagnosis? ... mucor cases may ... malnutrition, HIV, SLE ... therapy), some cases ... skin #clinical #photo
Papulosquamous Skin Rash - Differential Diagnosis Algorithm Erythrematous or violaceous papules & plaques with overlying scale •
Papulosquamous Skin Rash ... - Differential Diagnosis ... soles • Discoid Lupus ... Papulosquamous #SkinRash ... #Algorithm #causes
Drug Induced Lupus (DIL) • Epidemiology: -10% of all lupus cases, drug-dependent, 4:1 to 1:1 F:M
cases, drug-dependent ... NPSLE rare, Malar rash ... is rare in DIL, SCLE-DIL ... Discontinuation of causal ... #rheumatology #diagnosis
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
tract, and often causes ... mucositis - Rash ... such as systemic lupus ... strong sign of cutaneous ... vasculitis, and SLE
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