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diagnosis differential dermatology vasculitis classification druginduced management adverseeffects antiphospholipid apls benefits cryoglobulinemia cryoglobulins dil hcq hematology hydroxychloroquine hypercoagulable papulosquamous petechiae
Vesiculobullous Skin Rash - Differential Diagnosis Algorithm Vesicles Fragile/EasiIy Ruptured - Intraepidermal blisters, possibly crusts/erosions - Inflammatory
Vesiculobullous Skin Rash ... Bullous systemic lupus ... drug eruption #Vesicular ... Vesiculobullous #SkinRash ... #causes
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
cases, drug-dependent ... Rare (SSA+ for cutaneous ... Positive in 60-80% of cases ... #sle #comparison ... #table #rheumatology
Hydroxychloroquine - Risks and Benefits in Lupus Benefits: ↓ Disease activity, ↓ Flare, ↓ Damage, ↓ Corticosteroid dose,
Benefits in Lupus ... rare with ~100 cases ... insufficiency - Cuteanous ... Risks #Benefits #Lupus ... #sideeffects #rheumatology
Papulosquamous Skin Rash - Differential Diagnosis Algorithm Erythrematous or violaceous papules & plaques with overlying scale •
Papulosquamous Skin Rash ... Differential Diagnosis Algorithm ... soles • Discoid Lupus ... Papulosquamous #SkinRash ... #causes
Causes of Petechial Rash - Differential Diagnosis Algorithm Pinpoint areas (less than 2 mm) of hemorrhage, which
Causes of Petechial ... Diagnosis Algorithm ... Disruptions in vascular ... Autoimmune Vasculitis (lupus ... for hepatitis B and
Drug Induced Lupus (DIL) • Epidemiology: -10% of all lupus cases, drug-dependent, 4:1 to 1:1 F:M
cases, drug-dependent ... NPSLE rare, Malar rash ... Rare (SSA+ for cutaneous ... Discontinuation of causal ... #DIL #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
often causes arthritis ... bullous or vesicular ... mucositis - Rash ... such as systemic lupus ... differential #diagnosis #rheumatology
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... Vascular Sludging ... Henoch-Schönlein purpura) • Cutaneous ... (e.g. systemic lupus ... classification #rheumatology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Strong sign of cutaneous ... bullous or vesicular ... , mucositis • Rash ... often causes arthritis ... Differential #Diagnosis #Rheumatology
Antiphospholipid Syndrome (APLS) Testing - Hypercoagulable Workup Algorithm INDICATIONS FOR TESTING: • Vascular thrombosis
Hypercoagulable Workup Algorithm ... FOR TESTING: • Vascular ... chromosomal causes ... excluded Testing: • Lupus ... #diagnosis #hematology
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