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diagnosis rheumatology differential erythematosus lupus management systemic vasculitis autoimmune classification macrophage mas myopathy myositis polychondritis relapsing signs vasculitides
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
) General: Fever ... Photosensitivity, Butterfly rash ... effusion, Restrictive lung ... Demyelinating syndromes ... lesions Abdominal pain
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Macrophage Activation ... is the main clinical ... Petechial or purpuric rash ... ) • Heart, lung ... erythematosus [SLE
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
weight loss, and fever ... : • Joint pain ... Induced Lupus: • Symptoms ... to: Arthritis, Fever ... Chronic B-cell activation
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Coronary arteries - Fever ... mucositis - Rash ... Presentation - Systemic Symptoms ... Vasculitis: • Fevers ... vasculitis, and SLE
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
diseases, such as SLE ... Presentation: Systemic Symptoms ... Vasculitis: • Fevers ... , mucositis • Rash ... • Progressive symptoms
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
substantial muscle pain ... : • Gottron rash ... : • Muscle pain ... : Fever, joint pain ... : • Fever • Interstitial
Relapsing Polychondritis What is it? Recurrent inflammation of the cartilage in the body (Autoimmune disorder) Who? • Most frequently: 40
ethnicities Symptoms ... Sudden onset of pain ... + Nonspecific symptoms ... : Fever, weight ... such as: • SLE
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