10 results
Chronic Hepatitis B - Diagnosis and Management Algorithm

• Who to treat: Essentially treat the pts with
Diagnosis and Management ... Algorithm • ... absent the risk of reactivation ... #Algorithm #Diagnosis ... #Management #Treatment
Hypersensitivity Types and Their Mechanisms
Type I - lgE - Soluble antigen
 - Allergen-specific lgE antibodies bind
to complement activation ... Complement activation ... Hypersensitivity #Types #Classification ... #Pathophysiology ... Diagnosis #Reactions #Table
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH) Pathophysiology ... →Activation of CD8 ... IFN-y) → Excessive activation ... Cytopenia +++ (Plt, Hb ... Lymphohistiocytosis #diagnosis #management
Summary table of types of hypersensitivity reactions. 
Type 1
 - Mediators: lgE
 - Antigen Form: Soluble
Summary table of ... cell antigens, leading ... to complement activation ... types #allergy #table ... #classification
Antiarrhythmics Pharmacology Summary
Cardiac Conduction Phases:
Phase 0 - Ventricular Depolarization:
 • Na+ channels open leading to a
channels open leading ... Vaughan Williams Classification ... Inhibit B.adrenergic activation ... #Pharmacology #Classification ... #Classes #pathophysiology
HBV Reactivation Risk in IBD on Immunosuppression Algorithm
Risk of Reactivation
High Risk: >10% Risk
 • HBsAg+ /
HBV Reactivation ... Risk of Reactivation ... Waseem_AhmedMD #HBV ... #Reactivation # ... #diagnosis #management
Tuberculosis Overview

10 million new M. tuberculosis infections/year
Facultative intracellular rod-shaped bacteria
Multidrug-resistant tuberculosis (MDR-TB) accounts for 4.6% of
tuberculosis (LTBI) Pathophysiology ... Active TB: • HIV ... • Endogenous reactivation ... Inhibitor: • Risk of reactivation ... TB #Diagnosis #Management
Tuberculosis Overview

10 million new M. tuberculosis infections/year
Facultative intracellular rod-shaped bacteria
Multidrug-resistant tuberculosis (MDR-TB) accounts for 4.6% of
tuberculosis (LTBI) Pathophysiology ... Active TB: • HIV ... • Endogenous reactivation ... Inhibitor: • Risk of reactivation ... TB #Diagnosis #Management
Transverse Myelitis Overview

Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
monophasic Pathophysiology ... • Excessive activation ... simplex virus, HIV ... Brucellosis - Dengue, EBV ... Myelitis #diagnosis #management
Hemophagocytic Lymphohistiocytosis (HLH)

High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
by uncontrolled activation ... Infections (e.g., EBV ... MAS-HLH: Macrophage Activation ... Pathophysiology ... uncontrolled immune activation